A Complex Systems Approach to Epilepsy

1. Overview Rod Scott and Matt Mahoney
2. Systems biological approaches to the genetic complexity of the epilepsies Jeffrey L. Brabec, Montana Kay Lara, Anna L. Tyler and J. Matthew Mahoney
3. Transcriptomic and epigenomic approaches for epilepsy Anika Bongaarts, Jagoda Glowacka, Konrad Wojdan, Angelika Mühlebner, Eleonora Aronica and James D. Mills
4. Phenomenological mesoscopic models for seizure activity Maria Luisa Saggio and Viktor K. Jirsa
5. Computational modeling approaches to epilepsy Yujiang Wang, Gabrielle Marie Schroeder, Nishant Sinha and Peter Taylor
6. The baseline and epileptiform EEG: a complex systems approach Giridhar P. Kalamangalam and Mircea Chelaru
7. Neuronal approaches to epilepsy Rod Scott and Matt Mahoney
8. Mapping epileptic networks with scalp and invasive EEG: applications to epileptogenic zone localization and seizure prediction Manel Vila-Vidal and Adria Tauste Campos
9. A neuroimaging network-level approach to drug-resistant epilepsy Niels A. Foit, Fatemeh Fadaie, Andrea Bernasconi and Neda Bernasconi
10. Epilepsy as a complex network disorder: insights from functional MRI David Carmichael, Rory J. Piper and Fraser Aitken.

The epilepsies are devastating neurological disorders for which progress developing effective new therapies has slowed over recent decades, primarily due to the complexity of the brain at all scales. This reality has shifted the focus of experimental and clinical practice toward complex systems approaches to overcoming current barriers. Organized by scale from genes to whole brain, the chapters of this book survey the theoretical underpinnings and use of network and dynamical systems approaches to interpreting and modeling experimental and clinical data in epilepsy. The emphasis throughout is on the value of the non-trivial, and often counterintuitive, properties of complex systems, and how to leverage these properties to elaborate mechanisms of epilepsy and develop new therapies. In this essential book, readers will learn key concepts of complex systems theory applied across multiple scales and how each of these scales connects to epilepsy.

Rod C. Scott, University of Vermont
Rod C. Scott is Division Chief of Neurology at Nemours Children's Health, Professor of Neurology and Pediatrics at Thomas Jefferson University, Professor of Neurological Sciences at the University of Vermont, USA and Professor of Paediatric Neuroscience at UCL, UK. Dr Scott has over twenty years of experience managing children with severe epilepsies associated with cognitive and behavioral impairments.

J. Matthew Mahoney, University of Vermont
J. Matthew Mahoney is a Senior Computational Scientist at The Jackson Laboratory and Research Assistant Professor of Neurological Sciences at the University of Vermont. Dr Mahoney uses network theory to understand complex diseases, including the epilepsies and other neurological disorders. His research spans genetics and genomics, computer vision, and electrophysiology.

Contributors

Rod Scott, Matt Mahoney, Jeffrey L. Brabec, Montana Kay Lara, Anna L. Tyler, Anika Bongaarts, Jagoda Glowacka, Konrad Wojdan, Angelika Mühlebner, Eleonora Aronica, James D. Mills, Maria Luisa Saggio, Viktor K. Jirsa, Yujiang Wang, Gabrielle Marie Schroeder, Nishant Sinha, Peter Taylor, Giridhar P. Kalamangalam, Mircea Chelaru, Manel Vila-Vidal, Adria Tauste Campos, Niels A. Foit, Fatemeh Fadaie, Andrea Bernasconi, Neda Bernasconi, David Carmichael, Rory J. Piper, Fraser Aitken