Men's Reproductive and Sexual Health Throughout The Lifespan: An Integrated Approach To Fertility, Sexual Function, And Vitality

Section I. An Introduction to Men's Health Care:
1. How has men's health changed over the past two decades?
2. The business landscape of men's health
3. Urologic men's health, the internet, and social media
Section II. The Biology of Male Reproduction and Infertility:
4. Current understanding of the physiology and histology of human spermatogenesis
5. Male reproductive endocrinology
6. Sperm chromatin packaging and the toroid linker model
7. Ejaculation and sperm transport: physiology and clinical concerns
8. Genetic aspects of male infertility
9. The mechanistic and predictive utility of sperm epigenetics
10. Aging and environmental interactions with the sperm epigenome
11. The effects of aging on male fertility and the health of offspring
Section III. Clinical Evaluation and Treatment of Male Infertility:
12. Office evaluation of the infertile male
13. Medical management of male fertility
14. Surgical management of male infertility
15. Varicocele repair in the era of ICSI
16. Implementing genetic testing of male infertility in the clinic
17. Andrological care of the patient with spinal cord injury
18. Clinical fertility preservation decision making for prepubertal and postpubertal individuals with male gametes
19. Mental health considerations in the infertile male and couple
Section IV. Laboratory Evaluation and Treatment of Male Infertility:
20. The modern semen analysis: theory and techniques of ejaculate examination
21. The future of computer-assisted semen analysis in the evaluation of male infertility
22. Reactive oxygen species and sperm DNA damage
23. Clinical value of sperm DNA fragmentation tests
24. The current use of sperm function assays
25. Sperm selection in the laboratory
26. Methods to select ejaculated, epididymal, and testicular spermatozoa for assisted conception
27. Optimal sperm selection in the ICSI era
28. Microfluidics for sperm sample preparation and sperm identification
29. Practical concerns for patient semen banking
30. The potential future applications of in vitro spermatogenesis in the clinical laboratory
31. Spermatogonial stem cell culture and future of germline gene editing
Section V. Medical and Surgical Management of Issues of Male Health:
32. Hypogonadism in the male: evaluation and treatment
33. Selective androgen receptor modulators (SARMs) in the treatment of hypogonadism and men's health
34. Male fertility and testosterone therapy
35. Sleep and men's health
36. Molecular biology and physiology of erectile function and dysfunction
37. Evaluation of the male with erectile dysfunction
38. Lifestyle modifications for erectile dysfunction
39. Medical and surgical management of erectile dysfunction
40. Surgical management of Peyronie's disease
41. Medical management of BPH
42. Chronic orchialgia.

Approximately one in twenty men have sperm counts low enough to impair fertility but little progress has been made in answering fundamental questions in andrology or in developing new diagnostic tools or management strategies in infertile men. Many of these problems increase with age, leading to a growing population of men seeking help. To address this, there is a strong movement towards integrating male reproductive and sexual healthcare involving clinicians such as andrologists, urologists, endocrinologists and counselors. This book will emphasize this integrated approach to male reproductive and sexual health throughout the lifespan. Practical advice on how to perform both clinical and laboratory evaluations of infertile men is given, as well as a variety of methods for medically and surgically managing common issues. This text ties together the three major pillars of clinical andrology: clinical care, the andrology laboratory, and translational research.

Douglas T. Carrell, Utah Center for Reproductive Medicine
Douglas T. Carrell is Director of the Andrology and IVF laboratories at the University of Utah Center for Reproductive Medicine, Salt Lake City, Utah.

Alexander W. Pastuszak, University of Utah
James M. Hotaling is Associate Professor of Surgery (Urology) and Director of the Men's Health program at the University of Utah Center for Reproductive Medicine, Salt Lake City, Utah.

James M. Hotaling, Utah Center for Reproductive Medicine
Alexander W. Pastuszak is Assistant Professor of Surgery (Urology) in the Department of Surgery at The University of Utah School of Medicine in Salt Lake City, Utah.