Drs. Hansten and Horn have recently updated their pocket-sized drug-drug interaction booklet designed for busy practitioners. It is a small, easy-to-use reference covering the most frequently occurring clinically significant drug-drug interactions. The Top 100 Drug Interactions contains information on approximately 8,400 common drug interactions that are likely to be of clinical significance. Object and precipitant drugs are logically grouped to fit the monographs into a convenient pocket-sized booklet. Each interacting drug is listed in the index for easy reference.
The focus of the booklet is on drug interaction management options following a brief comment describing the interaction These options include alternative, non-interacting drugs that could be considered as substitutes for one drug of the interacting drug pair. Advice on how and when to clinically monitor patients receiving potentially interacting drugs is provided. In addition to the interaction monographs, the booklet contains a table listing 440 common drugs, the cytochrome P450 enzyme responsible for their metabolism, and any enzymes that the drug is currently known to inhibit or induce. Using this table, the practitioner will be able to predict potential drug-drug interactions that may not as yet have been reported. The Top 100 Drug Interactions is an inexpensive, convenient, authoritative reference on drug-drug interactions that all practitioners should consult when writing a new prescription.