Cytokines in the Genesis and Treatment of Cancer

About this book

Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into four sections, the volume’s first three parts focus on cytokines in the genesis of cancer. The final section describes the notable progress — both in animal models and humans — in demonstrating the use of cytokine or anticytokine therapies for the prevention and treatment of cancer. Cytokines in the Genesis and Treatment of Cancer brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer. Together, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field.

Written for: Cancer researchers, oncologists, pharmacologists, radiotherapists

Table of contents

Cytokines in the Genesis and Treatment of Cancer
Co-Editors: Michael A. Caligiuri and Michael T. Lotze

Introduction

1. Overview and Introduction to Cancer and Inflammation
Michael A. Caligiuri and Michael T. Lotze

Part I. Cytokines in the Genesis of Cancer

Infectious Agents, Cytokines and Cancer

2. Helicobacter Pylori
Richard M. Peek, Jr.

3. HTLV-1
Michael Lairmore and Lee Ratner

4. Herpes Viruses
Frank J. Jenkins and Heather R. Hensler

Cytokines and Carcinogenesis

5. TNF
Mark DeWitte, David J. Shealy, Marian Nakada, and G. Mark Anderson

6. TGF-Š
Alyssa R. Bonine, Brian K. Law and Harold L. Moses

7. Interleukin 1 (IL-1) Family of Cytokines
Michael T. Lotze

8. IL-4/13
Koji Kawakami and Raj Puri

9. IL-6 and Castleman's disease
Norihiro Nishimoto

10. Interleukin 10 (IL-10) Family of Cytokines
Shin-ichiro Fujii and Michael Lotze

11. Cytokines in Multiple Myeloma: Therapeutic Implications
Dharminder Chauhan, Teru Hideshima and Kenneth Anderson

12. Murine Cytokine Models and the Genesis of Cancer
Todd A. Fehniger, Megan A. Cooper, Michael A. Caligiuri

13. Experimental Models of Cytokines and Cancer Prevention
Mark J. Smyth, Erika Cretney, Shayna E.A. Street and Yoshihiro Hayakawa

Cytokines and Tumor Stroma/Metastasis

14. Cytokines in the Tumor Stroma
Michael C. Ostrowski

15. Cytokines and Angiogenesis in Tumors
Sharmila Roy-Chowdhury and Charles K. Brown

16. Chemokines and Receptor Expression in Tumor Progression
Paola Allavena, Federica Marchesi and Alberto Mantovani

17. The Biology of Cancer Cachexia: Role of TNF±
Denis Guttridge

Part II: Cytokines in The Treatment Of Cancer

18. IL-2
Kim Margolin and Joe Clark

19. IL-12
Timothy E. Bael and Jared Gollob

20. The Type I Interferon Family
Stergios J. Moschos, Gregory B. Lesinski, William E. Carson, III, and John M. Kirkwood

21. Combination Cytokine Therapy
Seth Cohen and Howard Kaufman

22. Novel Strategies for Targeting Cytokine Administration
Paul M. Sondel, Jackie Hank, Mark Albertini and Stephen D. Gilles

23. Cytokines and Cancer Vaccines
Hideho Okada and Michael T. Lotze

24. Anti-cytokine Therapy
Miguel A. Villalona-Calero

25. Cytokines in the Supportive Care of Cancer
John A. Glaspy