Genetic Switch

The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long–range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.

Contents

Chapter 1. The Master Elements of Control
Chapter 2. Protein–DNA Interactions and Gene Control
Chapter 3. Control Circuits–Setting the Switch
Chapter 4. How Do We Know–The Key Experiments
Chapter 5. 2004: New Developments
Appendices