Mitochondrial Dysfunction in Neurodegenerative Disorders

DESCRIPTION

As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration.

Mitochondrial Dysfunction in Neurodegenerative Disorders brings together contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of these diseases, guiding the reader through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, to the consequences of this dysfunction on neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets.

Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

TABLE OF CONTENTS

• An Introduction to Mitochondria.
• Neurodegeneration in Primary Mitochondrial Disorders.
• Mutations in Nuclear Genes that Affect Mitochondrial Function in Parkinson’s Disease.
• Common mtDNA Polymorphisms and Neurodegenerative Disorders.
• MtDNA Mutations in Brain Ageing and Neurodegeneration.
• Mitochondrial Dysfunction in Neurodegenerative Disease; Protein Aggregation, Autophagy and Oxidative Stress.
• Mitochondria, Sodium and Calcium in Neuronal Dysfunction.
• Mitochondrial Membrane Potential and Dynamics.
• Dysfunction of the Ubiquitin/Proteasome System and Mitochondria in Neurodegenerative Disease.
• Neuronal Mitochondrial Transport and Dysfunction.
• Mitochondrial Changes Associated With Demyelination: Consequences for Axonal Integrity.
• Modelling Mitochondrial Dysfunction in Neurodegenerative Disease.
• Could Understanding the Role Of Mitochondria in Neurodegeneration Lead to Treatment?