Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms

Description:

Thoroughly updated and expanded, this new Third Edition provides the latest information on dosage, forms, film defects, and polymer characterization. Written by renowned leaders in the field, Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms is easily the most comprehensive book available on the market today. New to the Third Edition: the interaction of drugs with functional polymers the influence of processing parameters on coating quality the stabilization of polymeric film coats plasticizers and their applications in pharmaceutical coatings adhesion of polymeric films to solid substrates basic properties of latex and pseudolatex colloidal dispersions Key topics included: polymer interactions with drugs and excipients physical aging of polymeric films a complete overview and in-depth analysis of recent advances in the field, which includes information on the latest equipment used to apply polymers to a pharmaceutical system illustrated examples explaining the appropriate steps to be taken in order to solve formulation, processing, and stability problems to achieve an optimized dosage form.

Contents:

Latex Emulsions for Controlled Drug Delivery. Aqueous Polymeric Coating for Modified Release Oral Dosage Forms. Processing and Equipment Considerations for Aqueous Coatings. Mechanical Properties of Polymeric Films Prepared from Aqueous Polymeric Dispersions. Plasticizers and Their Application in Pharmaceutical Coatings. Defects in Aqueous Film-Coated Tablets. Adhesion of Polymeric Films. Influence of Pigments in the Properties of Polymeric Coating Systems. Process and Formulation Factors Affecting the Drug Release from Pellets Coated with the Ethylcellulose Pseudolatex Aquacoat. Chemistry and Application Properties of Polymethacrylate Coating Systems. Application of HPMC and HPMCAS to aqueous film coating of Pharmaceutical Dosage Forms. Physical Properties of HPMC Solutions and Their Role in the Film Coating Process and the Quality of the Coated Product. Use of Opadry, Sureteric, and Sureleease for Aqueous Film Coating of Pharmaceutical Solid Dosage Forms. Aqueous-based Coatings and Microparticles in Matrix Tablet Formulations. Polymer Interactions with Drugs and Excipients. Properties of Aqueous Psuedolatex Dispersions of Biodegradable Polymers. Physical Aging of Polymeric Film Coats.

Author Biography:

JAMES W. MCGINITY is Professor of Pharmacy, College of Pharmacy, the University of Texas at Austin, received his B.Pharm. degree from the University of Queensland, Brisbane, Australia, and graduated with his Ph.D. degree in Physical Pharmacy from the University of Iowa, Iowa City. Dr. McGinity's current research includes film coating technology, hot melt extrusion, materials science, tablet technology, and modified release drug delivery systems. A keynote speaker at over 50 international conferences, Dr. McGinity has published more than 160 peer-reviewed articles, written over 25 book chapters in the field, and has been issued 23 U.S. patents. He is an AAPS Fellow, has refereed for many influential journals, and is on a select number of editorial boards, including Drug Development and Industrial Pharmacy, Pharmaceutical Development and Technology, and The European Journal of Pharmaceutics and Biopharmaceutics. LINDA A. FELTON is an Associate Professor of Pharmaceutics at the University of New Mexico, Albuquerque. She earned a B.S. in Pharmacy and a Ph.D. in Pharmaceutics from the University of Texas at Austin. Her research interests are focused on polymeric film coating technology, modified release systems, and topical/transdermal drug delivery. She has presented her work at national and international conferences and has published extensively in peer-reviewed journals. Dr. Felton is a reviewer for a number of pharmaceutical journals, and an editorial board member of Drug Development and Industrial Pharmacy. Dr. Felton has a joint appointment with the Department of Veteran's Affairs Cooperative Studies Program where she oversees the formulation development of clinical trials materials. She is a current member of AAPS, CRS, ISPE, and AACP.