Annual Review of Pharmacology and Toxicology, Vol. 53

Table of Contents

1. A Conversation with Paul Greengard
   Paul Greengard and Eric J. Nestler
2. Pharmacology of Iron Transport
   Shaina L. Byrne, Divya Krishnamurthy, and Marianne Wessling-Resnick
3. Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health
   Christophe Morisseau and Bruce D. Hammock
4. Epigenetic Mechanisms of Depression and Antidepressant Action
   Vincent Vialou, Jian Feng, Alfred J. Robison, and Eric J. Nestler
5. The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease
   Naval P. Shanware, Kevin Bray, and Robert T. Abraham
6. Small Molecule–Based Approaches to Adult Stem Cell Therapies
   Luke L. Lairson, Costas A. Lyssiotis, Shoutian Zhu, and Peter G. Schultz
7. G Protein–Coupled Receptor Deorphanizations
   Olivier Civelli, Rainer K. Reinscheid, Yan Zhang, Zhiwei Wang, Robert Fredriksson, and Helgi B. Schiöth
8. Pluripotent Stem Cell–Derived Hepatocytes: Potential and Challenges in Pharmacology
   Dagmara Szkolnicka, Wenli Zhou, Balta Lucendo-Villarin, andDavid C. Hay
9. Tyrosine Kinase Inhibitors: Views of Selectivity, Sensitivity, and Clinical Performance
   Alexander Levitzki
10. Creating Order from Chaos: Cellular Regulation by Kinase Anchoring
    John D. Scott, Carmen W. Dessauer, and Kjetil Taskén
11. Unnatural Amino Acids as Probes of Ligand-Receptor Interactions and Their Conformational Consequences
    Stephan A. Pless and Christopher A. Ahern
12. Cyclic Nucleotide Compartmentalization: Contributions of Phosphodiesterases and ATP-Binding Cassette Transporters
    Satish Cheepala, Jean-Sebastien Hulot, Jessica A. Morgan,Yassine Sassi, Weiqiang Zhang, Anjaparavanda P.
13. One Hundred Years of Drug Regulation: Where Do We Go from Here?
    Raymond L. Woosley
14. Autophagy in Toxicology: Cause or Consequence?
    Sten Orrenius, Vitaliy O. Kaminskyy, and Boris Zhivotovsky
15. Insights from Genome-Wide Association Studies of Drug Response
    Kaixin Zhou and Ewan R. Pearson
16. The Potential of HDAC Inhibitors as Cognitive Enhancers
    Johannes Gräff and Li-Huei Tsai
17. Molecular Mechanisms Deployed by Virally Encoded G Protein–Coupled Receptors in Human Diseases
    Silvia Montaner, Irina Kufareva, Ruben Abagyan, and J. Silvio Gutkind
18. Genetic Risk Prediction: Individualized Variability in Susceptibility to Toxicants
    Daniel W. Nebert, Ge Zhang, and Elliot S. Vesell
19. microRNAs as Mediators of Drug Toxicity
    Tsuyoshi Yokoi and Miki Nakajima
20. Role of Nrf2 in Oxidative Stress and Toxicity
    Qiang Ma
21. Direct-Acting Antiviral Agents for Hepatitis C Virus Infection
    Jennifer J. Kiser and Charles Flexner
22. Systems Pharmacology to Predict Drug Toxicity: Integration Across Levels of Biological Organization
    Jane P.F. Bai and Darrell R. Abernethy
23. Omics and Drug Response
    Urs A. Meyer, Ulrich M. Zanger, and Matthias Schwab
24. Renal Transporters in Drug Development
    Kari M. Morrissey, Sophie L. Stocker, Matthias B. Wittwer, Lu Xu, and Kathleen M. Giacomini
25. Structure-Function of the G Protein–Coupled Receptor Superfamily
    Vsevolod Katritch, Vadim Cherezov, and Raymond C. Stevens
26. Design of Peptide and Peptidomimetic Ligands with Novel Pharmacological Activity Profiles
    Victor J. Hruby and Minying Cai
27. Hepatic and Intestinal Drug Transporters: Prediction of Pharmacokinetic Effects Caused by Drug-Drug Interactions and Genetic Polymorphisms
    Kenta Yoshida, Kazuya Maeda, and Yuichi Sugiyama