Human Oral Mucosa: Development, Structure and Function is a new text that reflects
the considerable increase in knowledge of oral mucosa that has occurred in recent
years. Our understanding of the structure of oral mucosa is now established
at a molecular rather than a tissue or cellular level. This in turn has revealed
a level of function that was previously not suspected, including a sophisticated
barrier to the penetration of exogenous materials, and the synthesis of specific
antimicrobial compounds, representing components of the innate immune system.
There is also a growing realization of commonality in structure and function
between regions of oral mucosa and the mucosae of the esophagus and vagina.
The aim of the present volume is to provide a more sophisticated text on human oral mucosa than presently exists in textbooks and to bring together information that is otherwise to be found in separate, specialist volumes into a comprehensive text. It relates structure at the molecular, cellular and tissue level to function and to clinical behavior. The volume is directed to advanced students and researchers in oral biology, as well as those in allied areas of investigation, such as dermatology, gynecology, internal medicine and pathology.
Table of Contents
1 The functions of oral mucosa.
1.1 Oral mucosa: What is it and what does it do?
1.2 Functions of the oral mucosa.
2 The organization of oral mucosa.
2.1 Clinical features.
2.2 Component tissues and glands.
3 Oral epithelium.
3.1 Histological structure of oral epithelium.
3.2 Epithelial proliferation and turnover.
3.3 Molecular and cellular organization of oral epithelium.
3.4 Non-keratinocytes in the oral epithelium.
4 The interface between epithelium and connective tissue.
4.1 Organization of the normal interface.
4.2 Immune-mediated subepithelial blistering diseases (IMSEBDS).
5 Connective tissue.
5.1 Lamina propria.
5.2 Blood supply.
5.3 Nerve supply.
6 Regional differences in the oral mucosa.
6.1 Structural variations in different regions.
6.2 Junctions in the oral mucosa.
7 Development and aging of the oral mucosa.
7.1 Developmental stages of oral mucosa.
7.2 The control of mucosal development: epithelial–mesenchymal interaction.
8 Barrier functions of oral mucosa.
8.1 The permeability barrier.
8.2 Immunologic barrier function of oral mucosa.
9 Homologies in structure and function among mucosae: oral, esophageal, and vaginal mucosa.
9.3 Organization of the tissues of esophagus and vagina.
9.4 Non-keratinocytes in esophageal and vaginal mucosa.
9.5 Infl ammatory cells.
Christopher Squier has an international reputation for his
research on the structure and function of oral mucosa, being the author or co-author
of 200 books, chapters or peer-reviewed articles. He has received the Distinguished
Scientist Award in Oral Biology from the International Association for Dental
Kim Brogden is a professor in the Department of Periodontics and the Dows Institute for Dental Research at the University of Iowa. His work on innate immunity in mucosal diseases including oral mucosa is recognized worldwide and he is the author of over 155 books, chapters or peer reviewed publications.