"Salivary Diagnostics" surveys one of the most exciting areas of research in oral biology. Regarded as the mirror of the body, saliva has immense potential to yield real clinical improvements in our ability to diagnose, and hence treat, oral and systemic conditions. The composition of saliva and other oral fluids reflect the tissue fluid levels of therapeutic, hormonal, and immunological molecules, as well as the presence of markers for systemic and oral disease."Salivary Diagnostics" describes the nature of saliva, and the basis for its usefulness as a diagnostic fluid. The book then goes on to survey and review the field of research, moving on to detail the development of current technologies and the deciphering of the human salivary proteome. "Saliva Diagnostics" will be essential to researchers in this field, oral biologists, and pathologists, as well as physicians and dentists and those involved with laboratory diagnostics in an academic and commercial setting. "Salivary Diagnostics" brings together the leading experts in the field under the aegis of a luminary editor. This book represents an unparalleled guide to the academic, scientific, clinical, and commercial applications of saliva as a diagnostic fluid.
Forward .Preface.I. Background & Foundation.1. Salivary Gland Development And Regeneration.2. Salivary Gland Physiology Relevant To Diagnostics.3. Saliva: Properties and Functions.4. Saliva Collectors.5. Salivary Secretion in Health and Disease.6. Processing and Storage of Saliva Samples..II. Saliva Diagnostics.7. Historical Perspectives and Present.8. Diagnostics Other Than Blood.9. Perception of Saliva: Relevance to Clinical Diagnostics.10. Technology Development.11. Human Salivary Proteomics.12. Genomic Targets in Saliva.13. Point-Of-Care Diagnostics for Infectious diseases.14. Dental Caries Risk Assessment.15. Periodontal Disease Substance Abuse.16. Role of Saliva in Detection of Substance Abuse.17. Head and Neck Cancer.18. Sjogren's Syndrome.19. Salivary Gland Dysfunction Associated with Systemic Disease.20. Progression and treatment evaluation in diseases affecting salivary glands.21. The Uses of Saliva in Forensic Genetics.22. SPKB - Salivary Proteome Knowledge Base; A platform for collaborative proteomics research.III. Saliva Diagnostics- A New Industry..23. Commercialization of Oral Fluid Products and Technologies.24. Coverage and Reimbursement for Salivary Diagnostic Tests.25. Saliva Diagnostics in the Dentist's and Physician's Office.26. Salivary Hormones in Research and Diagnostics.27. Crossroads Between Saliva Diagnostics and Salivary Gland Gene Therapy.28. Saliva Diagnostics- A New Industry
David Wong is Associate Dean of Research, Professor of Oral Biology, Oral Biology & Medicine, and Director of Dental Research Institute at UCLA. Dr. Wong is a dentist-scientist focusing his research on the molecular determinants (genomic and proteomic) of head and neck cancer. His research has been continuously funded by the NIDCR and NCI for the past 18 years. He has achieved two 4-year award U01 awards from the NIDCR for the creation of the UCLA Collaborative Oral Fluid Diagnostic Research Center and the Human Salivary Proteome project.