Photodynamic Therapy of Ocular Diseases

Summary:

This unique text, authored by the individuals who pioneered the use of Photodynamic Therapy (PDT), is designed to provide clinicians with an understanding of the basic physics of PDT and the rationale and techniques of PDT in ophthalmology and especially in age-related macular degeneration. The different photosensitizers, lasers, and possible future use of this new therapeutic modality for other intraocular pathologies are also discussed. This text offers a step-by-step, detailed approach to the use of PDT, picking up where the scientific journal articles leave off.

Contents

Section I: Introduction to Photodynamic Therapy

• Chapter. 1: History of PDT - E.S. Gragoudas, M.D., J.W. Miller, M.D., L. Zografos, M.D.
• Chapter. 2: History of PDT - J.W. Miller, M.D., E.S. Gragoudas, M.D.
• Chapter. 3: Principles of Photodynamic Therapy

Section II: Pre-clinical Studies

• Chapter. 4: In vitro assessment and bioassay of photosensensitizers for ocular PDT
• Chapter. 5: Combination of PDT and anti-angiogenic drugs
• Chapter. 6: PDT for experimental choroidal neovascularization using Visudyne
• Chapter. 7: PDT for experimental choroidal neovascularization using ATX-S10 (Na)
• Chapter. 8: PDT for experimental choroidal neovascularization using Purlytin
• Chapter. 9: PDT for experimental choroidal neovascularization using Lu-Tex
• Chapter. 10: PDT for iris neovascularization
• Chapter. 11: Recovery after repeated PDT treatments for normal retina and choroid
• Chapter. 12: The ocular localization of photosensitizers
• Chapter. 13: PDT of experimental choroidal neovascularization using NP with 6
• Chapter. 14: PDT for experimental intraocular tumors

Section III: Clinical Studies

• Chapter. 15: PDT for AMD
  • Part. 1: PDT for age related macular degeneration: How to do it
  • Part. 2: Fluorescein angiography and optical coherence tomography in photodynamic therapy for CNV due to AMD
  • Part. 3: ICG angiography in photodynamic therapy of CNV
  • Part. 4: Subfoveal choroidal blood flow and its regulation After photodynamic therapy in choroidal neovascularization
  • Part. 5: Results of AMD trials using Visudyne; Phase 1 and 2)
  • Part. 6: Results of age related macular degeneration trials with Visudyne (TAP/ VIP)
• Chapter. 16: Verteporfin PDT in pathologic myopia
• Chapter. 17: Photodynamic Therapy of CNV CNV From Causes Other Than AMD and Pathologic Myopia
• Chapter. 18: Verteporfin therapy in clinical practice
• Chapter. 19: Incidence of eligible cases in clinical practice
• Chapter. 20: PDT with SnET2
• Chapter. 21: PDT with Lutex-early results at one month

Section IV: Angiography with photosensitizers

• Chapter. 22: Angiography With Visudyne
• Chapter. 23: Angiography with Lu-Tex
• Chapter. 24: Angiography with other dyes
• Chapter. 25: Future Directions