Basic Neurosciences with Clinical Applications

This single-author book covers basic aspects of neuroscience, including concepts of molecular biology, neurochemistry, and electrophysiology, and makes direct clinical correlations in a concise and coherent manner. Includes HOT TOPICS such as: · Recent advances in system neurobiology · Integration of pain and autonomic control systems · Cholinergic and monoaminergic systems controlling behavior · Neuronal microenvironment and mechanisms of injury

Features

· This concise, coherent text provides a link between basic science and clinical correlations. · Readers will benefit from the author’s expertise as an academic clinical neurologist. · This text provides a concise review of basic neuroscience concepts that are included in several qualifying examinations, including the National Boards.

Contents

• 1. General Principles of Organization and Function of the Nervous System: Basic and Emerging Concepts
• 2. Control of the Phenotype, Growth, and Survival in the Nervous System
• 3. Protein Processing, Membrane Organization, and Cytoskeleton
• 4. Determination of the Structure and Cell Identity of the Nervous System
• 5. Axon and Myelin: Structure, Development, and Plasticity
• 6. Synapses: Structural, Molecular, and Developmental Aspects
• 7. Ion Channels and Channelopathies
• 8. Neurotransmission and Neuromodulation at Chemical Synapses
• 9. Mechanisms of Synaptic Regulation and Plasticity: Calcium, Gases, Eicosanoids, Phosphorylation, Transcriptional Regulation, and Steroid Signaling
• 10. Central Excitatory Synapses and Synaptic Plasticity
• 11. Inhibitory Neurotransmission in the Central Nervous System: Neurochemistry and Pharmacology
• 12. Cortical Organization and Thalamocortical Circuits
• 13. Relay of Exteroceptive Information: Somatosensory, Visual, and Auditory Systems
• 14. Pain, Temperature, Visceral, Taste, and Olfactory Sensation: Integrated Information for Homeostasis, Adaptation, and Emotion
• 15. Processing of Information in the Cerebral Cortex
• 16. Motor Control: Sensorimotor Transformations and Motor Cortex
• 17. Basal Ganglia and Cerebellum: Functional Organization and Role in Control of Motor and Cognitive Behavior
• 18. Spinal and Brain-Stem Mechanisms of Motor Control: Reflexes and Pattern Generators for Control of Posture, Locomotion, Eye Movements, and Swallowing
• 19. Motor Unit
• 20. Peripheral Autonomic Control of Visceral Organs
• 21. Central Control of Homeostasis and Adaptation
• 22. Central Control of Circadian Rhythms and Sleep-Wake Cycle
• 23. Cholinergic and Monoaminergic Systems: Control of Cognition and Behavior
• 24. Limbic System: Emotion and Memory
• 25. Cortical Networks for Object Recognition, Language, Attention, and Executive Control of Behavior
• 26. Energy Metabolism in the Nervous System
• 27. Neuronal Microenvironment
• 28. Mechanisms of Neuronal Injury and Death