Chien Molecular Basis of Cardiovascular Disease. a Companion to Braunw

The 2nd Edition of this heralded companion to Braunwald's Heart Disease explores the molecular mechanisms of cardiology and the scientific advances that are changing the practice of cardiology today. International experts discuss the role of genetics in cardiovascular disease * the molecular basis of ischemic disease, thrombosis and hypertension * genetic mapping approaches to inherited disorders * biologically targeted agents for hypertension and heart failure * and much more. Abundant figures and tables illustrate key concepts.

Reviews

"The explosion of knowledge in this area makes guidance imperative. Molecular Basis of Cardiovascular Disease provides an excellent road map for the journey. It is an outstanding book."
-- NEJM

"A timely text that provides a comprehensive and up-to-date review of molecular biologic principles and their application to cardiovascular practice."
-- Journal of Vascular Surgery

Features

Addresses most common cardiovascular problems from a molecular standpoint.
Explores developing treatments for cardiovascular problems based on genetics.
Provides references to Braunwald's Heart Disease, 6th Edition

What's New

• Examines today's cutting edge advances in molecular cardiology and the future of gene therapy,
• Examines the implications of cellular cholesterol metabolism in health and disease. .
• Delivers up-to-date information on understanding the origin of inherited disease.

Contents

I. General Principles of Molecular Cardiology

Chapter 1: Biotechnology and Cardiovascular Medicine: Recombinant Protein Therapy (Hiroshi Ashikaga, Kenneth R. Chien)
Chapter 2: Human Genome Project and Cardiovascular Disease Genes (CC Liew, Victor J. Dzau)
Chapter 3: Model Organisms for Cardiac Disease Gene Discovery (Calum A. Macrae, Mark C. Fishman)
Chapter 4: Generation and Cloning of Genetically Modified Animals (Leon J. DeWindt, Pieter A. Doevendans, Kenneth R. Chien)
Chapter 5: Mouse Models of Human Cardiovascular Disease (Geir Christensen, Ju Chen, John Ross, Jr., Kenneth Chien)
Chapter 6: Towards Stem Cell Therapy (Pieter A. Doevendans, Christine Mummery, Kenneth Chien)
Chapter 7: Cardiovascular Signaling Pathways (Susan F. Steinberg, Michael Karin, Joan Heller Brown)
Chapter 8: Genetic Approaches to Cardiovascular Disease (Carl J. Vaughan, Craig T. Basson)
Chapter 9: Gene Transfer Approaches for Cardiovascular Disease (Elizabeth Nabel)

II. Cardiac Development and Congenital Heart Disease

Chapter 10: Cardiac Development and Congenital Heart Disease (Deepak Srivastava, Eric N. Olson)
Chapter 11: Development of Pacemaking and Cardiac Conduction System Lineages (Robert G. Gourdie, Steven W. Kubalak, Terrence X. O'Brien, Kenneth R. Chien, Takashi Mikawa)
Chapter 12: Cardiac Laterality and Congenital Heart Disease (Pilar Ruiz-Lozano, Angel Raya, Kenneth R. Chien, Juan Carlos Izpisua-Belmonte)
Chapter 13: Pharyngeal Apparatus and Cardiac Neural Crest Defects (Antonio Baldini)
Chapter 14: Monogenic Causes of Congenital Heart Disease (Joachim P. Schmitt, Christine E. Seidman)

III. Cardiac Muscle Diseases

Chapter 15: Molecular Pathways for Cardiac Hypertrophy and Heart Failure Progression (Masahiko Hoshijima, Susumu Minamisawa, Hideo Yasukawa, Kenneth R. Chien)
Chapter 16: Molecular Genetics of Inherited Cardiomyopathies (Christopher Semsarian, J.F. Seidman, and Christine E. Seidman)
Chapter 17: Molecular Pathways for Dilated Cardiomyopathy (K. Campbell)Chapter
18: Excitability and Conduction (Michael J. Ackerman, David E. Clapham)
Chapter 19: Cardiac Arrhythmias: Inherited Molecular Mechanisms (Steve A. N. Goldstein, Mark T. Keating, Michael C. Sanguinetti)

IV. Atherogenesis

Chapter 20: Inflammation and Immunity in Atherogenesis (Peter Libby, Göran K. Hansson and Jordan S. Pober)
Chapter 21: Molecular Biology of Lipoproteins and Dyslipidemias (Sotirios Tsimikas, Vincent Mooser)
Chapter 22: Lipoprotein Oxidation, Macrophages, Immunity and Atherogenesis (Sotirios Tsimikas, Christopher K. Glass, Daniel Steinberg and Joseph L. Witztum)
Chapter 23: Cellular Cholesterol Metabolism in Health and Disease (Ira Tabas)

V. Ischemic Diseases and Angiogenesis

Chapter 24: Angiogenesis in Cardiovascular Disease (Karen S. Moulton, Judah Folkman)
Chapter 25: Coronary Restenosis (Hiroshi Ashikaga, Ori Ben-Yehuda, Kenneth R. Chien)
Chapter 26: Molecular Basis for the Potential Use of NMDA Receptor Open-Channel Blockers in the Treatment of Cerebral Ischemia and Other Brain Insults (Stuart A. Lipton, Stephen F. Heinemann)

VI. Thrombosis

Chapter 27: Platelets and Anti-Platelet Therapy in Cardiovascular Disease: Molecular Mechanisms (Ori Ben-Yehuda)
Chapter 28: Blood Coagulation and Atherothrombosis (Hiroshi Ashikaga, Kenneth R. Chien)
Chapter 29: Thrombosis and Thrombolytic Therapy (H.R. Lijnen, H. Pannekoek, J. Vermylen)

VII. Hypertension

Chapter 30: Molecular Targets of Antihypertensive Drug Therapy (Edwin W. Williems, Ahsan Husain, Robert M. Graham)
Chapter 31: Mechanisms and Molecular Pathways in Hypertension (Roger Brown, John Mullins, David J. Webb)

VIII. Environmental and Genetic Modifiers of Cardiovascular Disease

Chapter 32: Molecular Biology of Transplantation and Xenotransplantation
(Patrick Hildbrand, Daniel R. Salomon)
Chapter 33: Viral Infections of the Heart (Kirk U. Knowlton, Hervé Duplain)

IX. Glossary: Resources, Websites