Inmunologic Disorders in Infants and Children

Fully revised and updated, this new fifth edition will include a new section devoted to secondary immunodeficiencies. New chapters in Section I include Dendritic Systems and Other Antigen Presenting Cells, as well as Natural Defense System and Immunology of Pregnancy. Section II contains new chapters on Severe Combined Immunodeficiency and Lymphocyte Apoptosis Syndromes. The final section of the book has been extensively updated, including revised material on immunizations.

What's New

• Presents two new editors and 30 new authors
• Features 10 new chapters , including The Natural Innate Defense System, The Immunology of Pregnancy, Apoptosis Syndromes, Periodic Fever Syndromes and more
• Includes new material on the immunodeficiencies of immaturity and HIV infection - two fast-moving areas
• Provides expanded coverage of the secondary immunodeficiencies section , including a new chapter on genetic syndromes
• Includes extended discussions on immunodeficiency of malnutrition , splenic deficiency, surgical and anaesthetic stress and burns
• Presents greater coverage of combined and isolated cellular (T-cell) immunodeficiencies... all told, it discusses over 100 primary immunodeficiencies
• Places more emphasis on oncology in the hematology chapter
• Provides an updated review of bone marrow and solid organ transplantation

Contents

Part I: Development and Function of the Immune System

1. Ontogeny of Immunity
2. The T-Lymphocyte System
3. The B-Lymphocyte System: Fundamental Immunology
4. The B-Lymphocyte System: Clinical Immunology
5. The Polymorphonuclear Leukocyte System
6. The Mononuclear Phagocytic, Dendritic Cell and Natural Killer Cell Systems
7. The Serum Complement System
8. The Immune Response: Generation, Regulation and Maintenance
9. The Mucosal Defense System
10. The Natural (Innate) Defense System
11. The Immunology of Pregnancy

Part II: Primary Immunodeficiencies

12. Immunodeficiency Disorders--General Considerations
13. Antibody Deficiencies
14. Disorders of the IgA System
15. Combined Immunodeficiencies
16. Combined Immune Deficiencies Due to Purine Enzyme Defects
17. Other Well Defined Immunodeficiencies
18. Chromosomal Breakage Syndromes
19. Autoimmune Lymphoproliferative Syndrome (ALPS)
20. Phagocyte Disorders
21. Deficiencies of the Complement System

Part III: Secondary Immunodeficiencies

22. The Physiologic Immunodeficiency of Immaturity
23. Immune Responses to Malnutrition
24. Genetic Disorders Including Syndromic Immunodeficiencies
25. Immune Deficiency in Metabolic Diseases
26. Proliferative and Histiocytic Disorders
27. Immunosuppressive by Therapeutic Agents and Environmental Conditions
28. Immune Mechanisms in Infectious Disease
29. Pediatric Human Immunodeficiency Virus Infection
30. Stress-related Immunodeficiencies: Trauma, Surgery, Anesthesia, Burns, Exercise and Splenic Deficiencies

Part IV: Immunologic Aspects of Pediatric Illness

31. Allergic Diseases
32. Dermatologic Disorders
33. Pulmonary Disorders
34. Gastroenterologic and Liver Disorders
35. Rheumatic Disorders
36. Periodic Fever Syndromes
37. Autoimmune Endocrinopaties
38. Renal Disorders
39. Immune Mediated Hematologic and Oncologic Disorders
40. Immunologic Disorders of the Nervous System
41. Infection in the Compromised Host
42. Active and Passive Immunization in the Prevention of Infectious Diseases
43. Transplantation

Appendices

1. CD Designations
2. Cytokines and Chemokines