Kirsner´s Inflammatory Bowel Diseases

This comprehensive New Edition describes all of the latest scientific and clinical advances in the field of inflammatory bowel disease (IBD). A new editorial team--joined by a superb group of international authorities--examine every aspect of IBD--including etiology and pathogenesis, diagnosis and evaluation, medical and surgical therapy, and more. A wealth of expanded coverage, additional international contributors, extensive updating throughout, and numerous diagnostic and therapeutic algorithms make this an essential resource.

Features

• Emphasizes evidence-based medicine in the section on medical therapy.
• Features a detailed description of inflammatory and immunologic pathways, allowing the reader to fully understand the contributing influences to the inflammation of IBD.
• Presents separate chapters on molecular genetics and clinical genetics for more in-depth coverage of each aspect of inflammatory bowel disease genetics.
• Provides a comprehensive review of IBD through abundant, high-quality endoscopic, radiographic, and histologic photographs--placing the various diagnostic modalities in perspective.
• Offers extensive coverage of postoperative recurrence of Crohn's disease pouchitis microscopic colitis perianal disease and osteoporosis.
  Includes up-to-the-minute guidance (including many 2003 references).

Contents

Section I. Mucosal protection and homeostasis

1. Intestinal epithelia barrier function: Characteristics and responses to neutrophil transeptithelial migration
2. Epithelial restitution and healing
3. Epithelial/microbial interactions
4. Epithelial/immune cell interactions
5. Regulatory T lymphocytes and dendritic cells
6. T lymphocyte trafficking
7. Leukocyte, platelet and endothelial cell interactions in inflammatory bowel disease

Section II. Etiology and pathogenesis

8. Genetics - molecular and chromosomal considerations
9. Animal models
10. Microbial influences on chronic intestinal inflammation
11. Mechanisms of tissue injury
12. Cytokines and inflammatory mediators
13. T lymphocyte dysregulation
14. Neuro-immune interactions in the inflamed bowel
15. Fibrogenesis
16. Cancer - molecular considerations

Section III. Epidemiology, Clinical Features and Natural History

17. Epidemiology
18. Clinical genetics of inflammatory bowel disease
19. Clinical features and natural history of ulcerative colitis
20. Clinical features and natural history of Crohn's disease
21. Clinical features and natural history of pediatric inflammatory bowel disease
22. Physiologic consequences of surgical treatment for inflammatory bowel disease
23. Fertility and Pregnancy
24. Psychosocial factors

Section IV. Diagnosis and Evaluation

25. Differential diagnosis of inflammatory bowel disease
26. Endoscopy
27. Pathology
28. Radiology
29. Serology and laboratory markers of disease activity

Section V. Medical Therapy

30. Assessment of disease activity and clinical trial design
31. Quality of life and pharmacoeconomics
32. Clinical pharmacology
33. Medical therapy for ulcerative colitis
34. Medical therapy for Crohn's disease
35. Medical and nutritional therapy for pediatric inflammatory bowel disease
36. Nutrition
37. Developing therapies for inflammatory bowel disease

Section VI. Surgical Therapy

38. Indications for surgery: A gastroenterologists opinion
39. Indications for surgery: A surgeon's opinion
40. Surgical management of ulcerative colitis
41. Surgical management of Crohn's disease
42. Management of enterostomy appliances

Section VII. Complications and Associated Diseases

43. Cancer: Clinical considerations
44. Primary Sclerosing cholangitis
45. Other extraintestinal manifestations
46. Pouchitis
47. Postoperative recurrence of Crohn's disease
48. Microscopic colitis
49. Perianal and fistulizing Crohn's disease
50. Osteoporosis

Index