Vascular cognitive impairment is the second most common cause of dementia after Alzheimer’s disease and is expected to grow in prevalence with the aging global population. The purpose of this authoritative book is to give a broad clinical perspective on vascular cognitive impairment and thus create a foundation for the implementation of good dementia care. The book focuses on pathophysiology, diagnosis, treatment and prevention. It demonstrates the underlying causes of the disorder, such as the manner in which vascular risk-factors influence the onset of vascular cognitive impairment. The concept of mixed forms of vascular dementia, Alzheimer’s dementia and other vascular diseases is discussed as well as the influence of vascular changes with regard to the onset of Alzheimer’s disease. The detailed section on pathophysiology will enhance clinicians’ understanding of this complex disorder. Finally there is a section on pharmacological and neuropsychological treatment of cognitive and psychiatric symptoms.
• Presents detailed information on treatment - practical advice on the management of patients with vascular cognitive impairment • Discusses the scientific background of vessel-dependent cognitive impairment - gives the reader insight into how vascular disease affects cognitive functioning • Advises the reader on how to use the most modern imaging devices as well as neuropsychological and neurochemical techniques to diagnose vascular dementia • Presents pharmacological and non-pharmacological treatment of cognitive and psychiatric symptoms
List of contributors; Preface; Part I. Diagnosis: 1. Diagnosing vascular cognitive impairment and dementia – concepts and controversies Timo Erkinjuntti and Serge Gauthier; 2. Vascular cognitive impairment - prodrome to VaD? Adriane Mayda and Charles DeCarli; 3. Clinical evaluation: a systematic but user-friendly approach Oscar L. Lopez and David A. Wolk; 4. Cognitive functioning in vascular dementia before and after diagnosis Erika J. Laukka, Sari Karlsson, Stuart W. S. MacDonald and Lars Bäckman; 5. Structural neuroimaging: CT and MRI Wiesje M. van der Flier, Salka S. Staekenborg, Frederik Barkhof and Philip Scheltens; 6. Functional imaging in vascular dementia – clinical practice Lars-Olof Wahlund and Rimma Axelsson; 7. Biomarkers in vascular dementia Anders Wallin and Tuula Pirttilä; Part II. Pathophysiology: 8. Physio-pathology of large vessel vascular dementia Leonardo Pantoni, Francesca Pescini and Anna Poggesi; 9. Small vessel diseases of the brain Raj N. Kalaria and Timo Erkinjuntti; 10. White matter changes Franz Fazekas, Christian Enzinger, Stefan Ropele and Reinhold Schmidt; 11. Hereditary forms of cerebrovascular amyloidosis Agueda Rostagno and Jorge Ghiso; 12. Role of vascular risk factors in dementia Chengxuan Qiu and Laura Fratiglioni; 13. Cardiovascular disease, cognitive decline, and dementia Angela L. Jefferson and Emelia J. Benjamin; 14. Vascular factors in Alzheimer’s disease: from diagnostic dichotomy to integrative etiology Miia Kivipelto, Alina Solomon and Tiia Ngandu; Part III. Treatment: 15. Treatment of cognitive changes Serge Gauthier and Timo Erkinjuntti; 16. Treatment of functional decline Lena Borell; 17. Treatment of behavioral symptoms in vascular dementia Catherine Cole and Alistair Burns; 18. Control of vascular risk factors Deborah Gustafson and Ingmar Skoog; Index.