Skeletal Function and Form: Mechanobiology of Skeletal Development, Ag

The intimate relationship between form and function inherent in the design of animals is perhaps nowhere more evident than in the musculoskeletal system. In the bones, cartilage, tendons, ligaments, and muscles of all vertebrates there is a graceful and efficient physical order.

This book is about how function determines form. It addresses the role of mechanical factors in the development, adaptation, maintenance, aging, and repair of skeletal tissues. The authors refer to this process as mechanobiology and develop their theme within an evolutionary framework. They show how the normal development of skeletal tissues is influenced by mechanical stimulation beginning in the embryo and continuing throughout life into old age. They also show how degenerative disorders such as arthritis and osteoporosis are regulated by the same mechanical processes that influence development and growth.

Skeletal Function and Form bridges important gaps among disciplines, providing a common ground for understanding, and will appeal to a wide audience of bioengineers, zoologists, anthropologists, paleontologists, and orthopedists.

Contents

Preface

1. Form and function

2. Skeletal tissue histomorphology and mechanics

3. Cartilage differentiation and growth

4. Perichondral and periosteal ossification

5. Endochondral growth and ossification

6. Cancellous bone

7. Skeletal tissue regeneration

8. Articular cartilage development and destruction

9. Mechanobiology in skeletal evolution

10. The physical nature of living things

Appendix A. Material characteristics

Appendix B. Structural characteristics

Appendix C. Failure characteristics.