Essential Evidence-Based Medicine

Description

Essential Evidence-Based Medicine teaches the principles of research study methodology and design so that the reader can become better at critically analysing scientific and clinical studies. It describes the basic elements needed to understand biostatistics and epidemiology as applied to health care studies, and how to become a more discriminating reader of the medical literature by adopting the skills of critical appraisal. This new edition is extensively edited and updated, and includes two entirely new chapters on critical appraisal of qualitative research and communicating risks and evidence to patients. The text is geared towards the new learner, and assumes little clinical experience, starting with the basic principles of critical appraisal. A CD-ROM accompanies the book to enable students to test their learning through a series of questions, with answers provided. This is an ideal introductory text for medical students, health sciences students and a wide range of other healthcare professionals.

• Easy to follow layout for students and teachers with examples of study designs and research issues • Includes new chapters on critical appraisal of qualitative research and communicating risks and evidence to patients • Accompanying CD-ROM for readers to test their learning through multiple choice and short answer questions

Contents

Preface; Acknowledgements; 1. A brief history of medicine and statistics; 2. What is evidence-based medicine?; 3. Causation; 4. The medical literature: an overview; 5. Searching the medical literature Sandi Pirozzo and Elizabeth Irish; 6. Study design and strength of evidence; 7. Instruments and measurements: precision and validity; 8. Sources of bias; 9. Review of basic statistics; 10. Hypothesis testing; 11. Type I errors and number needed to treat; 12. Negative studies and Type II errors; 13. Risk assessment; 14. Multivariate analysis; 15. Randomized clinical trials (RCTs); 16. Scientific integrity and the responsible conduct of research John E. Kaplan; 17. Applicability and strength of evidence; 18. Communicating evidence to patients Laura J. Zakowski, Shobhina G. Chheda and Christing S. Seibert; 19. Critical appraisal of qualitative research studies Steven R. Simon; 20. An overview of decision making in medicine; 21. Sources of error in the clinical encounter; 22. The use of diagnostic tests; 23. Utility and characteristics of diagnostic tests: likelihood ratios, sensitivity and specificity; 24. Bayes' theorem, predictive values, post-test probabilities, and interval likelihood ratios; 25. Comparing tests and using ROC curves; 26. Incremental gain and the threshold approach to diagnostic testing; 27. Sources of bias and critical appraisal of studies of diagnostic tests; 28. Screening tests; 29. Practice guidelines and clinical prediction rules; 30. Decision analysis and quantifying patient values; 31. Cost-effectiveness analysis; 32. Outcome analysis; 33. Meta-analysis and systematic reviews; Appendix 1. Levels of evidence and grades of recommendations; Appendix 2. Overview of critical appraisal; Appendix 3. Formulas; Appendix 4. Commonly used statistical tests; Appendix 5. Proof of Bayes' theorem; Appendix 6. Using balance sheets to calculate thresholds; Glossary; Bibliography; Index.

Contributors

Sandi Pirozzo, Elizabeth Irish, John E. Kaplan, Laura J. Zakowski, Shobhina G. Chheda, Christing S. Seibert, Steven R. Simon