No hay productos en el carrito



Biological Sequence Analysis. Probabilistic Models of Proteins and Nucleic Acids
Durbin, R. — Eddy, S. — Krogh, A. — Mitchison, G.
1ª Edición Abril 1998
Inglés
Tapa blanda
366 pags
643 gr
17 x 25 x null cm
ISBN 9780521629713
Editorial CAMBRIDGE
LIBRO IMPRESO
-5%
71,89 €68,30 €IVA incluido
69,13 €65,67 €IVA no incluido
Recíbelo en un plazo de
2 - 3 semanas
Description
Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.
Features
• A much-needed textbook in a new and rapidly expanding area of science
• Interdisciplinary - aimed at both biologists and computer scientists
• Up-to-the-minute - presents the most recent sequence analysis methods
and their underlying concepts in a coherent framework
Table of Contents
1. Introduction
2. Pairwise sequence alignment
3. Multiple alignments
4. Hidden Markov models
5. Hidden Markov models applied to biological sequences
6. The Chomsky hierarchy of formal grammars
7. RNA and stochastic context-free grammars
8. Phylogenetic trees
9. Phylogeny and alignment
Index.
Reviews
'This book fills an important gap in the bioinformatics literature and should
be required reading for anyone who is interested in doing serious work in biological
sequence analysis. For biologists who have little formal training in statistics
or probability, it is a long-awaited contribution that, short of consulting
a professional statistician who is well versed in molecular biology, is the
best source of statistical information that is relevant to sequence-alignment
problems. This book seems destined to become a classic. I highly recommend it.'
- Andrew F. Neuwald, Trends in Biochemical Sciences
'This book is a nice tutorial and introduction to the field and can certainly
be recommended to all who wish to analyse biological sequences with computer
methods. It can also serve as a basis for a university course for undergraduates.'
- Trends in Cell Biology
' … an enjoyable opportunity to see a blend of modeling and data analysis
at work on an important class of problems in the rapidly growing field of computational
biology.' - D. Siegmund, Short Book Reviews
© 2025 Axón Librería S.L.
2.149.0