Placental Bed Disorders. Basic Science and Its Translation to Obstetrics

Description

It is now recognized that defective placentation in the human is a cause of many pregnancy complications, such as spontaneous abortion, preterm labor and delivery, pre-eclampsia, intrauterine growth restriction, fetal death and abruptio placenta. These clinical disorders can often have long-term consequences into adulthood, causing cardiovascular disease, obesity and diabetes for the newborn as well as an increased risk of premature death in the mother. This is the first book to be entirely focused on the placental bed, bringing together the results of basic and clinical research in cell biology, immunology, endocrinology, pathology, genetics and imaging to consolidate in a single, informative source for investigators and clinicians. Its core aim is to explore new approaches and improve current clinical practice. This is essential reading for clinicians in obstetric, cardiovascular and reproductive medicine.

· First book to focus on the placental bed, bringing together all areas of relevant research
· 25 chapters from an expert multi-contributor team on all aspects of placental bed disorders
· Color images to aid understanding

Contents

Preface

Part I. Introducing the Placental Bed:
1. The placental bed in a historical perspective Robert Pijnenborg
2. Unraveling the anatomy Ivo Brosens

Part II. Placental Bed Vascular Disorders:
3. Defective spiral artery remodelling Ivo Brosens and T. Yee Khong
4. What is defective: decidua, trophoblast or both? Robert Pijnenborg and M. Hanssens

Part III. Uterine Vascular Environment:
5. Decidualisation Brianna Cloke, Luca Fusi and Jan Brosens
6. Uterine NK cells Ashley Moffett
7. Placental angiogenesis Christophe L. Depoix and Robert N. Taylor
8. Oxygen delivery at the deciduo-placental interface Eric Jauniaux and Graham J. Burton

Part IV. Deep Placentation:
9. The junctional zone myometrium Stephen R. Killick and Piotr Lesny
10. Subendometrial spiral artery blood flow and pregnancy rate Ernest Hung Yu Ng and Pak Chung Ho
11. Deep trophoblast invasion and spiral artery remodelling Robert Pijnenborg and Ivo Brosens

Part V. Comparative Anatomy and Research Models:
12. Comparative anatomy and placental evolution Anthony M. Carter and Robert D. Martin
13. Animal models of deep trophoblast invasion Robert Pijnenborg and Lisbeth Vercruysse
14. Trophoblast-arterial interactions in vitro J. E. Cartwright and G. St J. Whitley
15. Long-term effects of uteroplacental insufficiency in animals R. H. Lane, R. McKnight and Qi Fu

Part VI. Genetics:
16. Fertile soil or no man's land: a partial history of the placental bed David Haig
17. Search for susceptibility genes Linda Morgan
18. Imprinting Gudrun Moore and Sayeda Abu-Amero

Part VII. Risk Factors, Predictors and Future Management:
19. Risk factors of pre-eclampsia and SGA Rolv Skjaerven, Kari K. Melve and Lars J. Vatten
20. Angiogenic factors and pre-eclampsia May Lee Tjoa, Eliyahu Khankin, Sarosh Rana and S. Ananth Karumanchi
21. Assisted reproductive technology and the risk of poor pregnancy outcome Marc J. N. C. Keirse and Frans M. Helmerhorst
22. Periconceptual and early pregnancy approach Gordon C. S. Smith
23. New concepts and recommendations on clinical management and research Caroline Dunk, Sascha Drewlo, Leslie Proctor and John C. P. Kingdom
24. Disorders of the placental bed in the genesis of the great obstetrical syndromes Roberto Romero, Juan Pedro Kusanovic and Chong Jai Kim
Index.

About the Authors

Robert Pijnenborg, University Hospital Gasthuisberg, Leuven
Robert Pijnenborg is Professor, Department of Woman and Child, Katholieke Universiteit Leuven, Belgium.
Ivo Brosens, Leuven Institute for Fertility and Embryology
Ivo Brosens is Emeritus Professor at the Katholieke Universiteit Leuven, Belgium.
Roberto Romero, National Institute of Child Health and Human Development, Detroit
Roberto Romero is Chief, Perinatology Research Branch, Program Director for Obstetrics and Perinatology and Professor of Molecular Obstetrics and Genetics, Wayne State University School of Medicine, Detroit, USA.