Pharmacogenomics of Human Drug Transporters. Clinical Impacts

Description

Highlighting the internationally hot topic of pharmacogenomics and its influence on drug therapy, Pharmacogenomics of Human Drug Transporters reviews individual drug transporters, including specific transporter families and clinical implications. This book serves as a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body, and the reasons why individuals differ. The authors include sufficient detail to enable non-specialists to understand the principles and techniques and provides a practical, hands-on resource for researchers in pharmaceutical industry, academic research, and government agencies.

Table of contents

Preface
Contributors

Chapter 1: Introduction to pharmacogenomics of drug transporters
Marianne K DeGorter and Richard B Kim

Chapter 2: ADME Pharmacogenomics in Drug Development
Liangfu Chen and Joseph W. Polli

Chapter 3: Regulatory Perspective on Pharmacogenomics of Drug Metabolizing Enzymes and Transporters
Lei Zhang, Gilbert J. Burckart, Shiew-Mei Huang and Lawrence J. Lesko

Chapter 4: The Pharmacogenomics of Membrane Transporters Project
Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini

Chapter 5: Emerging new technology of SNP typing
Toshihisa Ishikawa and Yoshihide Hayashizaki

Chapters 6: OATP1A2, OAT1 and OAT3
Rommel G. Tirona

Chapter 7: OATP1B1, OATB1B3 and OATP2B1
Jörg König and Martin Fromm

Chapter 8: OCT (SLC22A) and OCTN Families
Sophie L. Stocker, Kathleen M. Giacomini, Arian Emami-Riedmaier and A. Matthias Schwab

Chapter 9: MATE (SLC47) Family

Atsushi Yonezawa andKen-ichi Inui
Chapter 10: PEPT (SLC15A) Family
Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato

Chapter 11: Nucleoside Transporters (SLC28 and SLC29) Family
Míriam Molina-Arcas and Marçal Pastor-Anglada

Chapter 12: P-Glycoprotein (MDR1/ABCB1)
Ingolf Cascorbi

Chapter 13: Bile Salt Export Pump BSEP (ABCB11): Role in Liver Physiology and Liver Disease
Gerd Ullak-Kublick and Bruno Stieger

Chapter 14: BCRP (ABCG2)
Agnes Basseville, Susan E. Bates, William D. Figg and Alex Sparreboom

Chapter 15: MRP2 (ABCC2) and MRP3 (ABCC3)
Anne T. Nies

Chapter 16: MRP4 (ABCC4)
Satish B.Cheepala, Mugdha Sukthankar and John D. Schuetz

Chapter 17: MRP8 (ABCC11)
Yu Toyoda and Toshihisa Ishikawa

Chapter 18: Future Perspectives
Toshihisa Ishikawa and Joseph Ware

Index