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Pharmacogenomics of Human Drug Transporters. Clinical Impacts
Ishikawa, T. — Kim, T. — König, J.
1ª Edición Mayo 2013
Inglés
Tapa dura
432 pags
2000 gr
15 x 25 x null cm
ISBN 9780470927946
Editorial WILEY
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Description
Highlighting the internationally hot topic of pharmacogenomics and its influence on drug therapy, Pharmacogenomics of Human Drug Transporters reviews individual drug transporters, including specific transporter families and clinical implications. This book serves as a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body, and the reasons why individuals differ. The authors include sufficient detail to enable non-specialists to understand the principles and techniques and provides a practical, hands-on resource for researchers in pharmaceutical industry, academic research, and government agencies.
Table of contents
Preface
Contributors
Chapter 1: Introduction to pharmacogenomics of drug transporters
Marianne K DeGorter and Richard B Kim
Chapter 2: ADME Pharmacogenomics in Drug Development
Liangfu Chen and Joseph W. Polli
Chapter 3: Regulatory Perspective on Pharmacogenomics of Drug Metabolizing
Enzymes and Transporters
Lei Zhang, Gilbert J. Burckart, Shiew-Mei Huang and Lawrence J. Lesko
Chapter 4: The Pharmacogenomics of Membrane Transporters Project
Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini
Chapter 5: Emerging new technology of SNP typing
Toshihisa Ishikawa and Yoshihide Hayashizaki
Chapters 6: OATP1A2, OAT1 and OAT3
Rommel G. Tirona
Chapter 7: OATP1B1, OATB1B3 and OATP2B1
Jörg König and Martin Fromm
Chapter 8: OCT (SLC22A) and OCTN Families
Sophie L. Stocker, Kathleen M. Giacomini, Arian Emami-Riedmaier and A. Matthias
Schwab
Chapter 9: MATE (SLC47) Family
Atsushi Yonezawa andKen-ichi Inui
Chapter 10: PEPT (SLC15A) Family
Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato
Chapter 11: Nucleoside Transporters (SLC28 and SLC29) Family
Míriam Molina-Arcas and Marçal Pastor-Anglada
Chapter 12: P-Glycoprotein (MDR1/ABCB1)
Ingolf Cascorbi
Chapter 13: Bile Salt Export Pump BSEP (ABCB11): Role in Liver Physiology and
Liver Disease
Gerd Ullak-Kublick and Bruno Stieger
Chapter 14: BCRP (ABCG2)
Agnes Basseville, Susan E. Bates, William D. Figg and Alex Sparreboom
Chapter 15: MRP2 (ABCC2) and MRP3 (ABCC3)
Anne T. Nies
Chapter 16: MRP4 (ABCC4)
Satish B.Cheepala, Mugdha Sukthankar and John D. Schuetz
Chapter 17: MRP8 (ABCC11)
Yu Toyoda and Toshihisa Ishikawa
Chapter 18: Future Perspectives
Toshihisa Ishikawa and Joseph Ware
Index
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