Quality in Laboratory Hemostasis and Thrombosis

Description

The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired hemorrhagic and thrombotic disorders. Rapid changes in the number and complexity of tests in this discipline have presented challenges for laboratories, as they develop quality programs for the oversight of this testing.

Quality in Laboratory Hemostasis and Thrombosis has been completely revised and updated to reflect the changing process of managing quality. The second edition provides information on all aspects of testing, from pre-analytic to analytic and result reporting, in addition to external quality assurance. Chapters throughout the book include the development of global guidelines for methods, as well as the preparation of international standard plasmas and reagents.

Designed to capture the elements of quality at all levels of the practice of laboratory hemostasis and thrombosis, this book will guide the reader through the development of a quality program to support all activities in the hemostasis laboratory, both simple and complex.

Table of contents

Contributors
Foreword by Frits R. Rosendaal
Preface

Part 1: General Quality Program

• 1 General Quality Planning in the Hemostasis Laboratory
  John D. Olson
• 2 Hemostasis Test Validation, Performance and Reference Intervals: International Recommendations and Guidelines
  Richard A. Marlar
• 3 Causes of Errors in Medical Laboratories
  Giuseppi Lippi, Emmanuel J. Favaloro
• 4 International Standards in Hemostasis
  Trevor W. Barrowcliffe, Anthony R. Hubbard
• 5 Sample Integrity and Pre-analytical Variables
  Dorothy (Adcock) Funk
• 6 Internal Quality Control in the Hemostasis Laboratory
  Steve Kitchen, F. Eric Preston, John D. Olson
• 7 External Quality Assessment in Hemostasis: Its Importance and Significance
  F. Eric Preston, Steve Kitchen, Alok Srivastava
• 8 The Unique Challenges of Hemostatic Testing in Children
  M. Patricia Massicotte, Mary E. Bauman, Vanessa Chan, Anthony K.C. Chan

Part 2: Quality in Coagulation Testing

• 9 Initial Evaluation of Hemostasis: Reagent and Method Selection
  Wayne L. Chandler
• 10 Assay of Factor VIII and Other Clotting Factors
  Steve Kitchen, F. Eric Preston
• 11 Application of Molecular Genetics to the Investigation of Inherited Bleeding Disorders
  Stefan Lethagen, Morten Dunø, Lars Bo Nielsen
• 12 Detecting and Quantifying Acquired Functional Inhibitors in Haemostasis
  Bert Verbruggen, Myriam Dardikh, Britta Laros-van Gorkom
• 13 Standardisation of D-dimer Testing
  Guido Reber, Philippe de Moerloose
• 14 Point-of-Care Testing in Hemostasis
  Chris Gardiner, Dianne Kitchen, Samuel Machin, and Ian Mackie

Part 3: Quality in Testing for Platelet Function and von Willebrand Disease

• 15 Diagnostic Assessment of Platelet Function
  Paquita Nurden, Alan Nurden, Martine Jandrot-Perrus
• 16 Laboratory Evaluation of Heparin-Induced Thrombocytopenia
  Theodore (Ted) E. Warkentin, Jane C. Moore
• 17 Laboratory Evaluation of von Willebrand Disease: Phenotypic Analysis
  Emmanuel J. Favaloro
• 18 Laboratory Analysis of von Willebrand Disease: Molecular Analysis
  Anne C. Goodeve, Ian R. Peake

Part 4: Quality in Thrombophilia Testing and Monitoring Anticoagulation

• 19 Quality Issues in Heritable Thrombophilia Testing
  Isobel D. Walker, Ian Jennings
• 20 Evaluation of Antiphospholipid Antibodies
  Michael Greaves
• 21 Monitoring Heparin Therapy
  Marilyn Johnston
• 22 Monitoring Oral Anticoagulant Therapy with Vitamin K Antagonists
  Armando Tripodi
• 23 Monitoring New Anticoagulants
  Elaine Gray, Steve Kitchen

Index

Edited by

Steve Kitchen, Clinical Scientist, Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital and Scientific Director, UK National External Quality Assessment Scheme (FQAS) for Blood Coagulation, Scientific Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK

John D Olson, Professor and Vice Chair for Clinical Affairs, Department of Pathology, University of Texas Health Sciences Centre, San Antonio, Texas, USA

F. Eric Preston, Emeritus Professsor of Haematology, University of Sheffield and Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulations, Sheffield, UK