Flavonoid Pharmacokinetics: Methods of Analysis, Preclinical and Clinical Pharmacokinetics, Safety, and Toxicology

Description

Highlighting the extremely important preclinical aspects of flavonoids, including pharmacokinetics and analysis in biological samples, Flavonoid Pharmacokinetics covers the methods of analysis and pharmacokinetics (preclinical and clinical) of flavonoids to help readers comprehend pharmacokinetic terminology, understand the large number of compounds that encompass the flavonoid family, appreciate the multiple analytical methods available, and assess preclinical and clinical pharmacokinetics of flavonoids and similar chemical-derived compounds. The book uses applicable examples in different preclinical species and humans to strengthen pharmacokinetic concepts and to demonstrate how they apply on the preclinical and clinical drug development process.

Table of contents

Foreword
Preface
Contributors

1 Polyphenols and Flavonoids: An Overview 1
Jaime A. Yáñez, Connie M. Remsberg, Jody K. Takemoto, Karina R. Vega-Villa, Preston K. Andrews, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies

2 Analysis of Flavonoids through Chromatography 71
Jody K. Takemoto, Stephanie E. Martinez, and Neal M. Davies

3 Chiral Methods of Flavonoid Analysis 117
Jaime A. Yáñez, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies

4 Preclinical Pharmacokinetics of Flavonoids 161
Jaime A. Yáñez, Casey L. Sayre, and Neal M. Davies

5 Clinical Pharmacokinetics of Flavonoids 195
Casey L. Sayre, Karen D. Gerde, Jaime A. Yáñez, and Neal M. Davies

6 Toxicology and Safety of Flavonoids 249
Stephanie E. Martinez, Neal M. Davies, and Jonathan K. Reynolds

7 Flavonoids and Drug Interactions 281
Jaime A. Yáñez, Nagendra V. Chemuturi, Scott W. Womble, Casey L. Sayre, and Neal M. Davies

Index 321