This book describes the principles, methods, and applications of PBPK modeling in the pharmaceutical industry. It addresses a growing need, as more and more pharma companies are integrating PBPK into their lead selection cycle and clinical development. Moving easily from theory to practice, the author presents coverage of both the principles and applications of PBPK modeling, exposing the power of this tool to improve the process of drug discovery and development. With end-of-chapter glossaries, extensive bibliographic references, and an emphasis on practical applications, this resource provides a much-needed single source for this important area.
Table of Contents
Section I. Principles and methods.
Chapter 1 Modelling in the pharmaceutical industry.
Chapter 2. Physiologically-based modeling.
Chapter 3. A review of pharmacokinetic principles.
Chapter 4. Physiological model for absorption.
Chapter 5. Physiological model for distribution.
Chapter 6. Physiological models for drug metabolism and excretion.
Chapter 7. Generic whole-body physiologically-based pharmacokinetic modeling.
Chapter 8. Variability, uncertainty and sensitivity analysis.
Chapter 9. Evaluation of drug-drug interaction risk with PBPK models.
Chapter 10. PBPK of biotherapeutics.
Section II. Applications in the pharmaceutical industry.
Chapter 11. Data integration and sensitivity analysis.
Chapter 12. Hypothesis generation and pharmacokinetic predictions.
Chapter 13. Integration of PBPK and pharmacodynamics.
Chapter 14. PBPK modeling of populations.
Chapter 15. PBPK models along the drug discovery and development value chain.