Dendrimer-Based Drug Delivery Systems. from Theory to Practice

Description

The opportunities and challenges of using dendrimers to improve drug delivery

Among pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have noted that the volume of a dendrimer increases when it has a positive charge. If this property can be applied effectively, dendrimers have enormous potential in drug delivery systems, directly supplying medication to targeted human organs.

With contributions from an international team of pioneers and experts in dendrimer research, this book provides a comprehensive overview of the latest research efforts in designing and optimizing dendrimer-based drug delivery systems. The book analyzes key issues, demonstrating the critical connections that link fundamental concepts, design, synthesis, analytical methodology, and biological assessment to the practical use of dendrimers in drug delivery applications. Topics covered include:

• Dendrimer history
• Synthesis
• Physicochemical properties
• Principles of drug delivery
• Applications in diverse biomedical fields

Dendrimer-Based Drug Delivery Systems reflects the authors' thorough review and analysis of the current literature as well as their own firsthand experience in the lab. Readers will not only discover the current state of the science, but also gain valuable insights into fruitful directions for future research. References at the end of each chapter serve as a gateway to the growing body of literature in the field, enabling readers to explore each individual topic in greater depth.

Pharmaceutical and biomedical researchers will find this book a unique and essential guide to the opportunities, issues, and challenges involved in fully exploiting the potential of dendrimers to improve drug delivery.

Table of Contents

• Preface
• Foreword
  Donald A. Tomalia
• Chapter 1. Dendrimer chemistry: Supramolecular perspectives and applications
  Charles N. Moorefield, Sujith Perera, and George R. Newkome
• Chapter 2. Physicochemical properties of dendrimers and dendrimer complexes
  Toyoko Imae
• Chapter 3. The use of dendrimers to optimize the physicochemical and therapeutic properties of drugs
  Stieger N., Liebenberg W., Aucamp M. E., and De Villiers M. M.
• Chapter 4. Biological properties of phosphorus dendrimers
  Anne-Marie Caminade, and Jean-Pierre Majoral
• Chapter 5. Dendrimer-based products: synthesis and biological evaluation
  Mohammad Najlah, Zhengyuan Zhou, and Antony D’Emanuele
• Chapter 6. Improving the biocompatibility of dendrimers in drug delivery
  Yiwen Li, Libo Zhao, and Yiyun Cheng
• Chapter 7. Degradable dendrimers for drug delivery
  Marc Gingras, and Myriam Roy
• Chapter 8. Design of stimuli-responsive dendrimers for biomedical purposes
  Chie Kojima
• Chapter 9. Dendrimer-based gene delivery systems: administration routes and in vivo evaluations
  Schatzlein A.
• Chapter 10. Triazinedendrimers for DNA and siRNA delivery: Progress, challenges, and opportunities
  Meredith A. Mintzer, Olivia M. Merkel, Thomas Kissel, and Eric E. Simanek
• Chapter 11. Dendrimer-coated carbohydrate residues as drug delivery Trojan horses in Glycosciences
  Yoann M. Chabre, and René Roy
• Chapter 12. Nuclear magnetic resonance techniques in the analysis of dendrimer-based drug delivery systems
  Xueyan Feng, Kun Yang, Jingjing Hu, Tongwen Xu, and Yiyun Cheng
• Chapter 13. Dendrimer-based medical nanodevices for magnetic resonance imaging applications
  Hongdong Cai, Mingwu Shen, and Xiangyang Shi
• Chapter 14. Dendrimer-related nanoparticle systems for computed tomography imaging
  Chen Peng, and Xiangyang Shi

Author Information

YIYUN CHENG, PhD, is a Full Professor of Biomedical Engineering at the School of Life Science of East China Normal University. His research interests focus on the biomedical applications of dendrimers and other dendritic polymers. Dr. Cheng has published more than forty peer-reviewed manuscripts in such journals as Nature Materials, Chemical Society Reviews, and Journal of the American Chemical Society.