Analytical Methods for Therapeutic Drug Monitoring and Toxicology

Description

This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.

Table of Contents

Preface.
MONOGRAPHS.

• Abacavir.
• Abecarnil.
• Acamprosate Calcium.
• Acebutolol Hydrochloride.
• Aceclofenac.
• Acemetacin.
• Acenocoumarol.
• Acetaminophen.
• Acetazolamide.
• Aconitine.
• Acrivastine.
• Acyclovir.
• Albendazole.
• Albuterol.
• Alcuronium Chloride.
• Alfentanil Hydrochloride.
• Alfuzosin Hydrochloride.
• Allobarbital.
• Allopurinol.
• Alprazolam.
• Alprenolol.
• Ambroxol Hydrochloride.
• Amikacin.
• Amiloride Hydrochloride.
• Amiodarone Hydrochloride.
• Amisulpride.
• Amitriptyline Hydrochloride.
• Amlodipine Besylate.
• Amobarbital.
• Amoxapine.
• Amoxicillin.
• Amphetamine.
• Amphotericin B.
• Ampicillin.
• Amprenavir.
• Amsacrine.
• Apomorphine Hydrochloride.
• Aripiprazole.
• Arotinolol Hydrochloride.
• Artemisinin.
• Artesunate.
• Aspirin.
• Atazanavir Sulfate.
• Atenolol.
• Azathioprine.
• Azithromycin.
• Baclofen.
• Barbital.
• Benactyzine Hydrochloride.
• Bendroflumethiazide.
• Benzthiazide.
• Benzylpenicillin Potassium.
• Betaxolol Hydrochloride.
• Biapenem.
• Bisoprolol Fumarate.
• Bromazepam.
• Bromisoval.
• Bromperidol.
• Brompheniramine Maleate.
• Buflomedil Hydrochloride.
• Bumetanide.
• Buparvaquone.
• Bupivacaine Hydrochloride.
• Buprenorphine.
• Bupropion Hydrochloride.
• Buspirone Hydrochloride.
• Busulfan.
• Caffeine.
• Candesartan Cilexetil.
• Canrenone.
• Capecitabine.
• Capreomycin Sulfate.
• Carbamazepine.
• Carbidopa.
• Carbinoxamine Maleate.
• Carboplatin.
• Carbromal.
• Carteolol Hydrochloride.
• Carvedilol.
• Caspofungin Acetate.
• Cathine.
• Cefaclor.
• Cefadroxil.
• Cefalexin.
• Cefazolin Sodium.
• Cefdinir.
• Cefditoren Pivoxil.
• Cefepime Hydrochloride.
• Cefixime.
• Cefotaxime Sodium.
• Cefozopran Hydrochloride.
• Cefpiramide.
• Cefpirome Sulfate.
• Cefpodoxime Proxetil.
• Cefprozil.
• Ceftazidime.
• Ceftibuten.
• Ceftiofur Hydrochloride.
• Ceftizoxime Sodium.
• Ceftriaxone Sodium.
• Cefuroxime.
• Celecoxib.
• Celiprolol Hydrochloride.
• Cephalexin Hydrochloride.
• Cetirizine Hydrochloride.
• Chloramphenicol.
• Chlordiazepoxide.
• Chlorhexidine Acetate.
• Chlorothiazide.
• Chlorphenamine Maleate.
• Chlorpromazine.
• Chlorpropamide.
• Chlorthalidone.
• Cilnidipine.
• Cimetidine.
• Ciprofloxacin.
• Cisapride.
• Cisplatin.
• Citalopram Hydrobromide.
• Clarithromycin.
• Clavulanate Potassium.
• Clemastine Fumarate.
• Clenbuterol Hydrochloride.
• Clinafloxacin Hydrochloride.
• Clobazam.
• Clofazimine.
• Clomipramine Hydrochloride.
• Clonazepam.
• Clonidine.
• Clopamide.
• Cloperastine.
• Clotiapine.
• Cloxacillin.
• Clozapine.
• Cocaine.
• Codeine.
• Cotinine.
• Cyclopenthiazide.
• Cyclophosphamide.
• Cyclosporine.
• Cyproheptadine Hydrochloride.
• Cytarabine.
• Dabigatran Etexilate.
• Dapsone.
• Daptomycin.
• Darunavir.
• Debrisoquine Sulfate.
• Decitabine.
• Delavirdine Mesylate.
• Derxazoxane.
• Desipramine Hydrochloride.
• Desloratadine.
• Dexamethasone.
• Dexfenfluramine Hydrochloride.
• Dextromethorphan Hydrobromide.
• Dextromoramide Tartrate.
• Diamorphine Hydrochloride.
• Diazepam.
• Dibenzepin Hydrochloride.
• Diclofenac Sodium.
• Diclofenamide.
• Dicloxacillin Sodium.
• Didanosine.
• Digoxin.
• Diltiazem Hydrochloride.
• Dimethylformamide.
• Dimethylsulfoxide.
• Diphemanil Metilsulfate.
• Diphenhydramine Hydrochloride.
• Diphenylpyraline Hydrochloride.
• Diprophylline.
• Dipyridamole.
• Dipyrone.
• Docetaxel.
• Donepezil Hydrochloride.
• Dopamine Hydrochloride.
• Doripenem.
• Dosulepin Hydrochloride.
• Doxapram Hydrochloride.
• Doxazosin Mesylate.
• Doxepin Hydrochloride.
• Doxifluridine.
• Doxofylline.
• Doxorubicin Hydrochloride.
• Doxycycline.
• Doxylamine Succinate.
• Droloxifene.
• Droperidol.
• Drospirenone.
• Ecabet Sodium.
• Efavirenz.
• Emedastine Difumarate.
• Emtricitabine.
• Enalapril Maleate.
• Enoxacin.
• Enoxolone (Glycyrrhetic Acid).
• Ephedrine Hydrochloride.
• Epinephrine.
• Eprosartan Mesylate.
• Erlotinib Hydrochloride.
• Ertapenem Sodium.
• Escitalopram Oxalate.
• Esmolol Hydrochloride.
• Estazolam.
• Ethacrynic Acid.
• Ethambutol Hydrochloride.
• Ethionamide.
• Ethosuximide.
• Ethotoin.
• Etodolac.
• Etoposide.
• Everolimus.
• Famotidine.
• Faropenem Sodium.
• Felbamate.
• Felodipine.
• Fenoterol.
• Fenretinide.
• Fentanyl Citrate.
• Fexofenadine Hydrochloride.
• Flavopiridol.
• Flecainide Acetate.
• Fleroxacin.
• Floxacillin.
• Fluconazole.
• Flucytosine.
• Flunarizine Hydrochloride.
• Flunitrazepam.
• Fluorouracil.
• Fluoxetine Hydrochloride.
• Flupentixol Decanoate.
• Fluphenazine Hydrochloride.
• Flurbiprofen Sodium.
• Fluvoxamine Maleate.
• Formic Acid.
• Furosemide.
• Gabapentin.
• Ganciclovir.
• Garenoxacin Mesylate.
• Gatifloxacin.
• Gemcitabine Hydrochloride.
• Gemfibrozil.
• Glibenclamide.
• Glimepiride.
• Gluconolactone.
• Griseofulvin.
• Haloperidol.
• Heptabarbital.
• Homochlorcyclizine Hydrochloride.
• Hydrochlorothiazide.
• Hydrocortisone.
• Ibafloxacin.
• Ibudilast.
• Ibuprofen.
• Ifenprodil Tartrate.
• Ifosfamide.
• Imatinib Mesylate.
• Imidafenacin.
• Imipenem.
• Imipramine.
• Indapamide.
• Indinavir Sulfate.
• Indomethacin.
• Iomeprol.
• Iprindole Hydrochloride.
• Irbesartan.
• Isepamicin.
• Isoniazid.
• Itraconazole.
• Kanamycin A.
• Ketamine Hydrochloride.
• Ketanserin.
• Ketobemidone Hydrochloride.
• Ketoconazole.
• Ketoprofen.
• Ketorolac Tromethamine.
• Ketotifen Fumarate.
• Labetalol Hydrochloride.
• Lacidipine.
• Lamivudine.
• Lamotrigine.
• Lansoprazole.
• Lapatinib Ditosylate.
• Lercanidipine Hydrochloride.
• Levetiracetam.
• Levocetirizine.
• Levodopa.
• Levofloxacin.
• Levomepromazine Hydrochloride.
• Levonorgestrel.
• Lidocaine.
• Lomefloxacin Hydrochloride.
• Lopinavir.
• Loratadine.
• Lorazepam.
• Losartan Potassium.
• Loxapine.
• Lysergide.
• Manidipine Hydrochloride.
• Maprotiline.
• Mefruside.
• Melitracen Hydrochloride.
• Meloxicam.
• Melperone Hydrochloride.
• Mepindolol Sulfate.
• Mercaptopurine.
• Meropenem.
• Mesalazine.
• Mesuximide.
• Metformin Hydrochoride.
• Methadone Hydrochloride.
• Methamphetamine Hydrochloride.
• Methcathinone.
• Methotrexate.
• Methyclothiazide.
• 3,4-Methylenedioxyamphetamine.
• 3,4-Methylenedioxymethamphetamine.
• Methylephedrine Hydrochloride.
• Metoclopramide Hydrochloride.
• Metolazone.
• Metoprolol.
• Metronidazole.
• Mexiletine Hydrochloride.
• Mianserin Hydrochloride.
• Midazolam Hydrochloride.
• Milnacipran Hydrochloride.
• Minocycline Hydrochloride.
• Minoxidil.
• Mirtazapine.
• Mitotane.
• Moclobemide.
• Modafinil.
• Montelukast Sodium.
• Morphine.
• Moxifloxacin.
• Mycophenolate Mofetil.
• Nadolol.
• Nafcillin Sodium.
• Naftifine Hydrochloride.
• Naproxen Sodium.
• Nateglinide.
• Nelfinavir Mesylate.
• Nevirapine.
• Nicardipine Hydrochloride.
• Nifedipine.
• Nimesulide.
• Nimodipine.
• Nisoldipine.
• Nitrazepam.
• Nitrendipine.
• Nizatidine.
• Nordazepam.
• Norepinephrine Bitartrate.
• Norfloxacin.
• Nortriptyline Hydrochloride.
• Nystatin.
• Octopamine.
• Ofloxacin.
• Olanzapine.
• Olopatadine Hydrochloride.
• Omeprazole.
• Opipramol Hydrochloride.
• Orphenadrine Citrate.
• Oxacillin Sodium.
• Oxazepam.
• Oxcarbazepine.
• Oxolinic Acid.
• Oxprenolol Hydrochloride.
• Paclitaxel.
• Paroxetine.
• Pasiniazide.
• Pefloxacin Mesylate.
• Pemoline.
• Penciclovir.
• Pentazocine Hydrochloride.
• Pentisomide.
• Pentobarbital.
• Pentoxifylline.
• Perazine Dimalonate.
• Perifosine.
• Perphenazine.
• Pethidine Hydrochloride.
• Phenazone.
• Phencyclidine Hydrochloride.
• Phenethylamine.
• Pheneturide.
• Phenobarbital Sodium.
• Penicillin V.
• Phenprocoumon.
• Phenylethanolamine.
• Phenytoin.
• Pimozide.
• Pindolol.
• Pipamperone.
• Piperacillin Sodium.
• Pipethanate Ethobromide.
• Pirarubicin.
• Piroxicam.
• Posaconazole.
• Prednisolone.
• Pregabalin.
• Primidone.
• Probenecid.
• Procainamide Hydrochloride.
• Proguanil Hydrochloride.
• Promethazine Hydrochloride.
• Propofol.
• Propranolol Hydrochloride.
• Protionamide.
• Protriptyline Hydrochloride.
• Pseudoephedrine.
• Pyrazinamide.
• Pyrimethamine.
• Quetiapine Fumarate.
• Quinethazone.
• Quinine Sulfate.
• Raltegravir Potassium.
• Ranitidine Hydrochloride.
• Reboxetine Mesylate.
• Resveratrol.
• Ribavirin.
• Rifampin.
• Rifapentine.
• Riluzole.
• Risperidone.
• Ritonavir.
• Rizatriptan Benzoate.
• Rofecoxib.
• Rogletimide.
• Ropivacaine Hydrochloride.
• Salicylic Acid.
• Saquinavir.
• Secbutabarbital Sodium.
• Secobarbital Sodium.
• Serotonin.
• Sertraline Hydrochloride.
• Sildenafil Citrate.
• Sirolimus.
• Sodium Valproate.
• Sotalol Hydrochloride.
• Sparfloxacin.
• Spironolactone.
• Stavudine.
• Sufentanil Citrate.
• Sulfadiazine.
• Sulfadoxine.
• Sulfamerazine.
• Sulfamethizole.
• Sulfamethoxazole.
• Sulfaquanidine.
• Sulpiride.
• Sultopride Hydrochloride.
• Sumatriptan Succinate.
• Tacrine Hydrochloride.
• Tacrolimus.
• Tadalafil.
• Tamoxifen Citrate.
• Tegaserod Maleate.
• Telithromycin.
• Telmisartan.
• Temazepam.
• Teniposide.
• Tenofovir.
• Terazosin Hydrochloride.
• Terbutaline Sulfate.
• Tertatolol Hydrochloride.
• Testosterone.
• Tetracaine Hydrochloride.
• Theobromine.
• Theophylline.
• Thioguanine.
• Thioridazine.
• Thiotepa.
• Tiapride Hydrochloride.
• Timolol Maleate.
• Tipranavir.
• Tobramycin.
• Tolbutamide.
• Toloxatone.
• Topiramate.
• Toremifene Citrate.
• Torsemide.
• Tosufloxacin.
• Tramadol Hydrochloride.
• Triamterene.
• Triazolam.
• Trimethoprim.
• Trimipramine.
• Triprolidine Hydrochloride.
• Tryptophan.
• Tyramine Hydrochloride.
• Valacyclovir Hydrochloride.
• Valganciclovir Hydrochloride.
• Valproic Acid.
• Vancomycin Hydrochloride.
• Venlafaxine Hydrochloride.
• Verapamil Hydrochloride.
• Vigabatrin.
• Viloxazine Hydrochloride.
• Vincristine Sulfate.
• Vinorelbine Tartrate.
• Voriconazole.
• Vorinostat.
• Warfarin Sodium.
• Zalcitabine.
• Zidovudine.
• Zolmitriptan.
• Zonisamide.
• Zopiclone.
• Zotepine.
• Zuclopenthixol Hydrochloride.

Index.

Author Information

Q. Alan Xu, PhD, is a Research Scientist in the Pharmacology and Analytical Facility at the University of Texas MD Anderson Cancer Center. He has written seventy scientific papers, book chapters, and one book.

Timothy L. Madden, PharmD, DABCP, FCCP, is an Associate Professor in the Department of Experimental Therapeutics and Director of the Pharmaceutical Development Center at the University of Texas MD Anderson Cancer Center. He is a consultant for numerous pharmaceutical companies, holds fifteen patents, and has written more than 100 peer-reviewed papers, abstracts, and book chapters.