Cardiovascular Effects of Inhaled Ultrafine and Nano-Sized Particles

Description

This book assists scientists, toxicologists, clinicians, and public health regulators to understand the complex issues that determine the impact of air pollution on the cardiovascular system. It covers a range of relevant topics including particulate matter (PM) sources and characterization, methods of exposure, impact of PM on cells and systems, role of particles in the pathophysiology of cardiovascular disease, risk assessment, and potential environmental and therapeutic interventions.

Table of Contents

About the editors.
Preface.
Forword (Paul Borm).
List of authors.

Section I. Issue framing.

• 1. Overview.
• 2. Acute effects of particulate matter on cardiovascular events.
• 3. Chronic effects of particulate matter on cardiovascular disease.

Section II. Exposure.

• 4. Particle characterization.
• 5. Exposure assessment ambient ultrafine particles.
• 6. From exposure to dose.
• 7. Translocation of Inhaled Nanoparticles.
• 8. Role of chemical composition in determining the cardiovascular effects of particles.

Section III. Methodology.

• 9. In vitro studies.
• 10. Experimental studies in animals.
• 11. Human exposure studies.
• 12. Panel studies.

Section IV. Particles and cardiovascular disease -mechanisms.

A. ATHEROGENESIS.

• 13. Particulates and oxidative stress.
• 14. Role of inflammation in the atherogenic effects of particulate matter.
• 15. Inhaled particles, postprandial lipids and their possible contribution to atherogenesis.
• 16. Inhaled particulate matter and atherosclerosis in humans.

B. VASCULAR DYSFUNCTION .

• 17. Effects of particulates on the pulmonary vasculature.
• 18. Particulate Matter, Hypertension, and the Metabolic Syndrome.
• 19. Particles and the vascular endothelium.

C. THROMBOSIS.

• 20. Particles, coagulation and thrombosis.
• 21. Particles and the pathogenesis of atherothrombosis.

D. ARRHYTHMIA (NLM to edit).

• 22. Particles and the autonomic nervous system.
• 23. Air pollution and cardiac arrhythmia.

Section V. Environmental and public health policy.

• 24. Risk assessment.
• 25. Environmental regulation of particulate matter.
• 26. From ambient ultrafine particles to nanotechnology and nanotoxicology.

Author Information

Flemming R. Cassee is head of the Department of Inhalation Toxicology, deputy head of the Center for Environmental Health, and leader of the program on air pollution and health at the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Nicholas L. Mills is a British Heart Foundation Clinical Fellow at the University of Edinburgh and Specialist Registrar in Cardiology at the Royal Infirmary of Edinburgh.

David E. Newby is the British Heart Foundation John Wheatley Chair of Cardiology at the University of Edinburgh. He is a Consultant Interventional Cardiologist at the Royal Infirmary of Edinburgh, Director of the Wellcome Trust Clinical Research Facility, Director of the Clinical Research Imaging Centre, and Director of Research and Development for NHS Lothian.