Oral Bioavailability. Basic Principles, Advanced Concepts, and Applications

DESCRIPTION

Understand and assess the design, delivery, and efficacy of orally administered drugs

A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability.

The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen

This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery.

In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches—Caco-2 cell culture model, MDCK, and other related cell culture models—which are used to study the science of oral bioavailability.

TABLE OF CONTENTS

• Foreword.
• Preface.
• Contributors.

1. Barriers to Oral Bioavailability-An Overview (Ming Hu and Xiaoling Li).
2. Physicochemical Characterization of Pharmaceutical Solids (Smita Debnath).
3. Solubility of Pharmaceutical Solids (Lauren Wiser, Xiaoling Gao, Bhaskara Jasti, and Xiaoling Li).
4. In Vitro Dissolution of Pharmaceutical Solids (Josephine L. P. Soh and Paul W. S. Heng).
5. Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption (Paul C. Ho).
6. Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways (Miki Susanto Park and Jae H. Chang).
7. In vitro-In vivo Correlation of Pharmaceutical Dosage Forms (Deliang Zhou and Yihong Qiu).
8. Drug Metabolism in Gastroinestinal Tract (Rashim Singh and Ming Hu).
9. Efflux of Drugs via Transporters: The “Anti-absorption” Pathways (Jae H. Chang, James A. Uchizono and Miki Susanto Park).
10. Liver Drug Metabolism (Leslie M. Tompkins, and Hongbing Wang).
11. Protein Binding of Drugs (Antonia Kotsiou and Christine Tesseromatis).
12. Urinary Excretion of Drugs and Drug Reabsorption (Pankaj Gupta, Bo Feng and Jack Cook).
13. Pharmacokinetic Behaviors of Orally Administered Drugs (Jaime A. Yáñez, Dion R. Brocks, M. Laird Forrest, and Neal M. Davies).
14. Effects of Food on Drug Absorption (Venugopal P. Marasanapalle, Xiaoling Li, and Bhaskara R. Jasti).
15. Drug-Drug Interactions and Drug-Dietary Chemical Interactions (Ge Lin, Zhong Zuo, Na Li, and Li Zhang).
16. Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rates, Dogs, and Humans (Ayman El-Kattan, Susan Hurst, Joanne Brodfuehrer, Cho-Ming Loi).
17. Amino Acid Drug Transporters (Zhong Qiu Liu, and Ming Hu).
18. Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide Based Pharmaceuticals (David J. Lindley, Stephen M. Carl, Dea Herrera-Ruiz, Li F. Pan, Lori B. Ward, Jonathan M. E. Goole, Olafur S. Gudmundsson, and Gregory T. Knipp).
19. Organic Anion and Cation Drug Transporters (Takashi Sekine and Hiroshi Kusuhara).
20. Gastroretentive Drug Delivery Systems (John R. Cardinal and Avinash Nangia).
21. Lipid Based and self-emulsifying Oral Drug Delivery Systems (Sravan Penchala, Anh-Nhan Pham, Ying Huang and Jeffrey Wang).
22. Prodrug Strategies to Enhance Oral Drug Absorption (Sai H.S. Boddu, Deep Kwatra, and Ashim K. Mitra).
23. Oral Delivery of Protein/Peptide Therapeutics (Puchun Liu and Steven Dinh).
24. ABC Transporters in Intestinal and Liver Efflux (Marilyn E. Morris and Yash A. Gandhi).
25. Interplay between Efflux Transporter and Metabolic Enzymes (Stephen Wang).
26. Regulatory Considerations in Metabolism- and Transporter-Based Drug Interactions (Yuanchao (Derek) Zhang, Lei Zhang, John M. Strong, Shiew-Mei Huang).
27. Caco-2 Cell Culture Model for Oral Drug Absorption (Kaustubh Kulkarni and Ming Hu).
28. MDCK Cells and Other Cell Culture Models of Oral Drug Absorption (Deep Kwatra, Sai H. S. Boddu, Ashim K. Mitra).
29. Intestinal Perfusion Methods for Oral Drug Absorption (Wei Zhu and Eun-Jung (Zenobia) Jeong).
30. Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion (Cindy Q. Xia, Chuang Lu, and Suresh K. Balani).
31. In vivo Methods for Oral Bioavailability Studies (Ana Ruiz-Garcia and Marival Bermejo).
32. Determination of Regulation of Drug Metabolizing Enzymes and Transporters (Bin Zhang and Wen Xie).
33. Computational and Pharmacoinformatic Approaches to Oral Bioavailability Prediction (Miguel Ángel Cabrera-Pérez, and Isabel González-Álvarez).

• Index.

AUTHOR

Ming Hu, PhD, is Professor of Pharmaceutics at the College of Pharmacy, University of Houston. Dr. Hu is on the editorial boards of Molecular Pharmaceutics and the Journal of Alternative and Complementary Medicine.

Xiaoling Li, PhD, is Professor of Pharmaceutics and Associate Dean of Graduate Education and Research at the Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific. He is a Fellow of the American Association of Pharmaceutical Scientists.