Quantitative Imaging Tools for Lung Cancer Drug Assessment

Description

Presents chapters written by leading clinical researchers in the field of lung cancer, where high resolution 3-D imaging technology appears to hold the greatest near-term promise, as well as contributions from recognized experts in CAD, medical information technology systems, regulatory procedure, x-ray standards development, and clinical trial design. These expert contributors discuss the current state of the art and provide a road map for directing further research in lung cancer as well as other organ systems.

Table of Contents

Preface (Thomas M. Baer and James L. Mulshine).

Chapter 1: Incorporating Imaging into Drug Development: An Industry Perspective (Philip S. Murphy and Debasish Roychowdhury).

Chapter 2: Developing Imaging Tools for Drug Development: Critical Technology, Clinical Data and Regulatory (Rafal Dziadziuszko, Fred R. Hirsch and Paul A. Bunn, Jr).

Chapter 3: Quantitative Imaging in CT Lung Cancer Drug Development and Evaluation (Ricardo S. Avila).

Chapter 4: Volumetric CT Imaging for Response Assessment in Lung Cancer: A Platform for Translational Research (Binsheng Zhao and Lawrence H. Scwhartz).

Chapter 5: Emerging Radiological Software Standards and Development Technologies: Impact on Clinical Translation and Trials (John Pearson, Lawrence Tarbox, Gianluca Paladini, John G. Wolodzko, Paula M. Jacobs, and Zhenghong Lee).

Chapter 6: Statistical Considerations Underlying Therapeutic Response Criteria for Lung Cancer: A Review in the Context of Emergence of Multi-Slice CT Scanner and Computer Assisted Diagnostic Algorithm for Volumetric Assessment (Madhu Mazumdar and Xi Kathy Zhou).

Chapter 7: Programs Supporting Quantitative Imaging in Biomedicine at the National Institute for Standards and Technology (Thomas M. Baer and Charles W. Clark).

Appendix A: Evolving Imaging Resources: Public Access Databases (Laurence Clarke).

Appendix B: Biomedical Imaging Archive Network (Thomas M. Baer and James L. Mulshine).

Appendix C: Developing CT Image-Processing Tools to Accelerate Progress in Lung Cancer Drug Development (James L. Mulshine, Ricardo S. Avila, Fred R. Hirsch, and David Yankelevitz).