Basic Immunology. Functions and Disorders of the Immune System

Instructions for online access

Cover image

Title page

Table of Contents

Copyright

Dedication

Preface

1. Introduction to the Immune System: Nomenclature, General Properties, and Components
Infections and Immunity
Immunologic Disorders
Stages of Host Defense: Innate and Adaptive Immunity
Properties of Adaptive Immune Responses
Cells of the Adaptive Immune System
Tissues of the Immune System
Summary

2. Unlabeled image.Innate Immunity: The Early Defense Against Infections
General Features and Specificity of Innate Immune Responses
Cellular Receptors for Microbes and Damaged Cells
Components of Innate Immunity
Innate Immune Reactions
Role of Innate Immunity in Stimulating Adaptive Immune Responses
Summary

3. Antigen Presentation to T Lymphocytes and the Functions of Major Histocompatibility Complex Molecules: What T Lymphocytes See
Antigens Recognized by T Lymphocytes
Capture of Protein Antigens by Antigen-Presenting Cells
Structure and Function of Major Histocompatibility Complex Molecules
Processing and Presentation of Protein Antigens
Functions of Antigen-Presenting Cells in Addition to Antigen Display
Antigen Recognition by Other T Lymphocytes
Summary

4. Antigen Recognition in the Adaptive Immune System: Structure of Lymphocyte Antigen Receptors and Development of Immune Repertoires
Antigen Receptors of Lymphocytes
Development of B and T Lymphocytes
Summary

5. T Cell–Mediated Immunity: Activation of T Lymphocytes
Steps in T Cell Responses
Antigen Recognition and Costimulation
Biochemical Pathways of T Cell Activation
Functional Responses of T Lymphocytes to Antigen and Costimulation
Regulation of T Cell Responses by Inhibitory Receptors (Coinhibitors)
Migration of T Lymphocytes in Cell-Mediated Immune Reactions
Decline of the Immune Response
Summary

6. Effector Mechanisms of T Cell–Mediated Immunity: Functions of T Cells in Host Defense
Types of T Cell–Mediated Immune Reactions
Development and Functions of CD4+ Effector T Lymphocytes
Differentiation and Functions of CD8+ Cytotoxic T Lymphocytes
Resistance of Pathogenic Microbes to Cell-Mediated Immunity
Summary

7. Humoral Immune Responses: Activation of B Lymphocytes and Production of Antibodies
Phases and Types of Humoral Immune Responses
Stimulation of B Lymphocytes by Antigen
Functions of Helper T Lymphocytes in Humoral Immune Responses
Antibody Responses to T-Independent Antigens
Regulation of Humoral Immune Responses
Summary

8. Effector Mechanisms of Humoral Immunity: Elimination of Extracellular Microbes and Toxins
Properties of Antibodies That Determine Effector Functions
Neutralization of Microbes and Microbial Toxins
Opsonization and Phagocytosis
Antibody-Dependent Cellular Cytotoxicity
Immunoglobulin E– and Mast Cell–Mediated Reactions
The Complement System
Functions of Antibodies at Special Anatomic Sites
Evasion of Humoral Immunity by Microbes
Vaccination
Summary

9. Immunologic Tolerance and Autoimmunity: Self–Nonself Discrimination in the Immune System and Its Failure
Immunologic Tolerance: General Priniciples and Significance
Central T Lymphocyte Tolerance
Peripheral T Lymphocyte Tolerance
B Lymphocyte Tolerance
Tolerance to Commensal Microbes and Fetal Antigens
Autoimmunity
Summary

10. Tumor and Transplantation Immunology: Immune Responses to Cancer Cells and Normal Foreign Cells
Immune Responses Against Tumors
Immune Responses Against Transplants
Summary

11. Hypersensitivity: Disorders Caused by Immune Responses
Types of Hypersensitivity Reactions
Immediate Hypersensitivity
Diseases Caused by Antibodies Specific for Cell and Tissue Antigens
Diseases Caused by Antigen-Antibody Complexes
Diseases Caused by T Lymphocytes
Summary

12. Immunodeficiency Diseases: Disorders Caused by Defective Immunity
Primary (Congenital) Immunodeficiencies
Acquired (Secondary) Immunodeficiencies
Acquired Immunodeficiency Syndrome (AIDS)
Summary

Appendix I. Principal Features of Selected CD Molecules

Appendix II. Cytokines

Appendix III. Clinical Cases

Answers to Review Questions

Index

Meticulously reviewed and updated for today's medical students, Basic Immunology, 7th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, Cellular and Molecular Immunology. This focused, easy-to-understand volume has been fully revised to include recent important advances in our understanding and knowledge of the immune system. A student favorite through six outstanding editions, this new edition uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter review questions, glossary terms, and clinical cases—all designed to help you master this complex topic in the most efficient, effective manner possible.

 

 

AUTHORS

Abul K. Abbas, MBBS, Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California

Affiliations and expertise
Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California Emeritus

Andrew Lichtman

Affiliations and expertise
Associate Professor of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA

 

Shiv Pillai

Affiliations and expertise
Massachusetts General Hospital Cancer Center, Boston, MA, USA