This volume in the Foundations in Diagnostic Pathology Series packs today's most essential cell and tissue base molecular pathology into a compact, high-yield format! It focuses on the state of the art in practical validated molecular diagnostics as applied across the fields of surgical pathology and cytology. With an emphasis on current, clinically valid, and diagnostically important applications today and in the near future, you can be assured you’re getting the most up-to-date, authoritative coverage available. Its pragmatic, well-organized approach, nearly 250 full-color illustrations, and at-a-glance boxes and tables make the information you need easy to access. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice!
- Offers detailed discussions on today’s technologies to help you select the best test for case evaluation.
- Presents recognized molecular pathologists who convey the most current information, keeping you on the cusp of your field.
- Features nearly 250 full-color illustrations that present important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases.
- Uses a consistent, user-friendly format, including at-a-glance boxes and tables for easy reference.
Table of Contents
SECTION I. MOLECULAR PRINCIPLES
Chapter 1 Molecular Biology Basics for the Pathologist, Ilka Warshawsky
Chapter 2 Quality Assurance of Molecular Assays, Wayne W. Grody
SECTION II. MOLECULAR TOOLS AND TECHNIQUES
Chapter 3 Overview of Molecular Diagnostic Techniques and Instrumentation, Daniel H. Farkas and Carol A. Holland
Chapter 4 Conventional and Real Time Polymerase Chain Reaction (PCR), Aaron Bossler and Vivianna Van Deerlin
Chapter 5 Loss of Heterozygosity, Jennifer L. Hunt
Chapter 6 Direct Genome Sequencing in Diagnostic Pathology, Gurunathan Murugesan and Gary W. Procop
Chapter 7 Array-Based Comparative Genomic Hybridization in the Analysis of Genomic Alterations in Human Disease, Marek Skacel, Ana Ambu Siva, and Raymond R. Tubbs
Chapter 8 Expression Arrays: Discovery and Validation, Neal Poulin and Torsten O. Nielsen
Chapter 9 Epigenetics: DNA Hypermethylation in Cancer, Bin Yang
Chapter 10 Tissue Microarrays, Ziad Peerwani
Chapter 11 Fluorescence in Situ Hybridization, James R. Cook
Chapter 12 Bright Field in Situ Hybridization, Ricardo V. Lloyd, Xiang Qian, and Long Jin
Chapter 13 Immunoglobulin and T-Cell Receptor Gene Rearrangement, Margaret L. Gulley
Chapter 14 Monitoring of Minimal Residual Hematologic Disease, Cuihong Wei, Jeffrey H. Lipton, and Suzanne Kamel-Reid
Chapter 15 Molecular Detection of Circulating Tumor Cells, Karen L. Kaul
Chapter 16 Intraoperative Molecular Staging Using Real-Time PCR, Tony E. Godfrey
SECTION III. DIAGNOSTIC MOLECULAR PATHOLOGY APPLICATIONS
Chapter 17, Molecular Cytopathology, Karen S. Gustafson and Douglas P. Clark
Chapter 18 Molecular Diagnosis of Infectious Agents in Tissue, Randall T. Hayden and Gary W. Procop
Chapter 19 Molecular Neuropathology, Richard Prayson
Chapter 20 Molecular Pathology of the Cardiovascular System, Carmela D. Tan and E. Rene Rodriguez
Chapter 21 Molecular Pulmonary Pathology, Samuel Yousem and Sanja Dacic
Chapter 22 Molecular Dermatopathology, Alexander J.F. Lazar, Jason W. Nash, and Abdul Hafeez Diwan
Chapter 23 Molecular Gastrointestinal, Liver, and Pancreatic Pathology, Rish K. Pai, Rebecca Wilcox, and John Hart
Chapter 24 Molecular Endocrine Pathology, Jennifer L. Hunt
Chapter 25 Molecular Hematopathology, James R. Cook
Chapter 26 Molecular Pathology of Bone and Soft Tissue Tumors, Brian P. Rubin, Alexander J.F. Lazar, and Andre Oliveira
Chapter 27 Molecular Pathology of Breast Cancer, David G. Hicks
Chapter 28 Molecular Genitourinary Pathology, Donna E. Hansel, Cristina Magi-Galluzzi, and Ming Zhou
Chapter 29 Molecular Gynecologic Pathology, Monica Prasad Hayes, Edyta C. Pirog, and Lora Hedrick Ellenson
Chapter 30 Pediatric Molecular Pathology, Robin LeGallo
By Raymond R. Tubbs, DO, Chairman, Department of Clinical Pathology, Cleveland Clinic Foundation, Cleveland, OH; and Mark H. Stoler, MD, Professor of Pathology, Cytology and Gynecology, Associate Director of Surgical Pathology and Cytopathology, University of Virginia Health System, Charlottesville, VA