Ghrh, Gh, and Igf1

TABLE OF CONTENTS

Preface

Contributors

PART I. OVERVIEW OF PHYSIOLOGY OF THE GHRH-SOMATOSTATIN-GH-IGF-I AXIS

• 1. Physiology of the Growth Hormone Releasing Hormone-Somatostatin-Growth Hormone-Insulin-Like Growth Factor I Axis - LAWRENCE A. FROHMAN
• 2. Role of Somatostatin in the Regulation of Growth Hormone Secretion - SEYMOUR REICHLIN
• 3. Growth Hormone Releasing Hormone and Growth Hormone Releasing Peptides - MARY LEE VANCE, JOSEPH A. ALOI, MARK L. HARTMAN, SUSAN E. KIRK, AND MICHAEL O. THORNER
• 4. GH Binding Protein, GH Receptors. and Domains Involved in Signal Transduction - P.A. KELLY, J. FINIDORI, M.-C. POSTEL-VINAY, M. EDERY, L. GOUJON, A. SOTIROPOULOS, H. DINERSTEIN, AND J.-J. LEBRUN
• 5. Insulin-Like Growth Factors During Development .... - DEREK LEROITH, STEFAN NEUENSCHWANDER, ANTOLII KOVAL, CHARYSE SINDLER, AND CHARLES T. ROBERTS, JR.

PART II. EFFECTS OF RECOMBINANT HUMAN GH AND/OR IGF-I IN CATABOLIC ILLNESS

• 6. Anabolic Effects of Recombinant Human Growth Hormone and Insulin-Like Growth Factor I in Human Disease - RAYMOND L. HINTZ
• 7. Growth Hormone in Children with Chronic Renal Disease: Some Metabolic Considerations - D.F. GEARY AND K. WELCH
• 8. Growth Hormone: The Visible Difference in Burn Care - MICHAEL J. MULLER, THOMAS C. RUTAN, AND DAVID N. HERNDON
• 9. Effects of Recombinant Human Growth Hormone on Body Composition and Metabolism in HIV-Associated Wasting - K. MULLIGAN, C. GRUNFELD, M.K. HELLERSTEIN, R.A. NEESE, AND M. SCHAMBELAN
• 10. Administration of Growth Hormone as an Adjunct to Nutritional Support in Critical Illness - THOMAS R. ZIEGLER
• 11. Strategies for the Use of Recombinant Human Growth Hormone and Insulin-Like Growth Factor I in Amyotrophic Lateral Sclerosis - BARRY W. FESTOFF, SHI X. YANG, AND DAVID STONG

PART III. CONTEMPORARY ISSUES IN GROWTH AND DEVELOPMENT

• 12. Contemporary Issues in Growth and Development: An Overview - GEORGE A. WERTHER
• 13. Use of Recombinant IGF-I in Syndromes of GH Insensitivity - RON G. ROSENFELD, ARLAN L. ROSENBLOOM, AND JAIME GUEVARA-AGUIRRE
• 14. Use of Growth Hormone in Non-Growth-Hormone-Deficient Children: Physiologic, Pharmacologic, and Ethical Issues - BARRY B. BERCU, HOWARD J. HEINZE, AND RICHARD F. WALKER
• 15. Growth Hormone Treatment of Nonelderly Adults with GH Deficiency - JENS S. CHRISTIANSEN, JENS O.L. JORGENSEN, NINA VAHL, ANDERS JUUL, JORN MULLER, AND NIELS E. SKAKKEBAEK

PART IV. EFFECTS OF rhGH AND IGF-I ON INTERMEDIARY AND BONE METABOLISM

• 16. Overview ot Growth Hormone and IGF-I Effects on Intermediary Metabolism and Bone - SHLOMO MELMED
• 17. Effects of rhGH on Glucose, Lipid, and Amino Acid Metabolism - KENNETH C. COPELAND AND K. SREEKUMARUN NAIR
• 18. Metabolic Effects of IGF-I: Implications for the Therapy of Diabetes Mellitus - ROBERT S. SHERWIN, WALTER P. BORG, AND SUSAN D. BOULWARE
• 19. Modulation of Responses to GH and IGF-I by Nutritional Variables - DAVID K. SNYDER
• 20. Growth Hormone Effects on the Adult Skeleton - ROBERT MARCUS
• 21. Insulin-Like Growth Factors and Skeletal Remodeling - JULIE PATTERSON, JAY R. SHAPIRO, AND MARC R. BLACKMAN

PART V. USE OF GHRH, rhGH, AND rhIGF-I IN AGING

• 22. Growth Hormone and Aging: A Brief Review - S. MITCHELL HARMAN AND MARC R. BLACKMAN
• 23. Potential Benefits and Risks in Treating the Hyposomatomedinemia and Hypogonadism of Elderly Men - DANIEL RUDMAN AND KAUP R. SHETTY
• 24. Effects of Growth Hormone Releasing Hormone Administration in Healthy Aging Men - M.R. BLACKMAN, J. VITTONE, E. CORPAS, J. BUSBY-WHITEHEAD, T. STEVENS, M.F. BELLANTONI, M. ROGERS, K. STEWART, J. TOBIN, R. SPENCER, AND S.M. HARMAN
• 25. Effects of Recombinant Human Insulin-Like Growth Factor I in Aging - ANDREW R. HOFFMAN, ROBERT MARCUS, RAYMOND L. HINTZ, GAIL BUTTERFIELD, JANICE THOMPSON, LAURA GHIRON, STEVEN LIEBERMAN, ELISABETTA DALL'AGLIO, AND GIAN PAOLO CEDA
• 26. Growth Hormone and Immune Function in the Elderly - WILLIAM H. ADLER, JAMES E. NAGEL, S. MITCHELL HARMAN, EMILIANO CORPAS, AND MARC R. BLACKMAN
• 27. Treatment with Growth Hormone: Focus on Specificity with View to the Future - JESSE ROTH

Author Index

Subject Index