Reproductive Endocrinology

About this book

Modern reproductive biology encompasses every level of biological study from genomics to ecology, encompassing cell biology, biochemistry, endocrinology and general physiology. All of these disciplines require basic knowledge, both as a tool and as an essential aid to a fundamental understanding of the principles of life in health and disease. Overall, molecular biology is central to scientific studies in all living matter, impacting disciplines such as medicine, related health sciences, veterinary, agriculture and environmental sciences.

In Reproductive Endocrinology: A Molecular Approach, the basic biochemistry of nucleic acids and proteins are reviewed. Methodologies used to study signaling and gene regulation in the endocrine/reproductive system are also discussed. Topics include mechanisms of hormone action and several endocrine disorders affecting the reproductive system. Professionals in the medical, veterinary and animal sciences fields will find exciting and stimulating material enhancing the breadth and quality of their research.

Written for: Graduate students and professionals in endocrinology and medical research fields.

Keywords:

• endocrinology
• genomics
• molecular biology
• reproduction

Table of contents

Introduction to the Molecular Organization of the Endocrine/Reproductive System.- Hormone Receptors.- Second Messenger Pathways.- Introduction to Molecular Biology: Structure and Function of the Macromolecules of Genetic Information.- Regulation of Gene Expression.- Recombinant DNA Technology.- Techniques for DNA Analysis.- Analyzing Gene Expression.- Reporter Gene Assays.- Use of Computers in Molecular Biology.- Prostaglandins and their Mechanisms of Action in the Cyclic Female Reproductive Tract.- FSH: One Hormone with Multiple Forms or a Family of Multiple Hormones.- The FSH receptor: One Receptor with Multiple Forms or a Family of Receptors.- The Adipokines.- Epigenetic Regulation of Gene Expression in the Ovary.- Transcriptional Regulation of the Steroid Acute Regulatory Protein (StAR).- Regulation of Steroidogenesis.- Neurosteroids & Reproductive Behavior.- Regulation of Apoptosis in the Ovary.- Structure and Function of Telomere and Telomerase in Mammals.- Genetic Basis of Abnormal Genotype.- Molecular Basis of Androgen Actions and Disorders.- Introduction to Gene Therapy in the Reproductive System.- Gene Targeting in Embryonic Stem Cells.- Molecular Basis of Pharmacological Interventions in the Reproductive System.- Appendix I: Amino Acids Codes.- Appendix II: Steroids Nomenclature.- Appendix III: Glossary of Terms.- Index.