Adrenocortical Carcinoma. Basic Science and Clinical Concepts

ABOUT THIS BOOK

· The book is motivated by the "First Annual International Adrenal Cancer Symposium: Clinical and Basic Science" held in the spring of 2008

· Offers an exciting combination of science, clinical care and resources for the physician and patient

We anticipate the book to be a definitive text on the subject that explores all aspects of the study of adrenal cancer and the treatment of patients with the disease. Chapters will cover epidemiology, pathogenesis, genetics, cancer stem cells, historic and emerging therapies, mouse models of adrenal cancer, new developments in tumor profiling, worldwide collaborative groups and tumor registries together with resources for the practitioner and community of adrenal cancer scientists.

We do not wish this book to compete with the other larger books in the Endocrine and Endocrine Surgery literature. In addition, it is not expected to cover benign adrenal diseases that have been covered in detail in other venues. We envision this book to be a very specialized and exhaustive text on basic, translational and clinical aspects of adrenal cancer.

Written for » Research
Related subjects » Cancer Research - Pharmaceutical Science

TABLE OF CONTENTS

a. History

1. General History
2. Scientific approach to an Orphan disease
3. History of treatment Schteingart

b. Epidemiology

1. Epidemiology of ACC Fassnacht

c. Pathogenesis

1. Childhood ACC Ribiero
2. Adult ACC
3. Genetics of ACC Kirschner
4. Viruses & ACC Balu
5. Telomerase & ACC Hornsby/Else
6. Inhibin & ACC Hammer
7. Li Fraumeni, p53 & ACC Zambetti
8. Beckwith Wiedemann & ACC (Smith AC)
9. Genomic instability & ACC
10. Beta-Catenin, Gardener & ACC Kim/Hammer
11. Insights from recent profiling Bertherat/Giordano
12. Cell Cycle of ACC
13. Somatostatin receptors in ACC Petersenn
14. DNA Methylation & locus control in ACC relevant genes
15. IGF2 H19 locus control Reik
16. Adrenal & IGF Weber
17. Zac1 and locus control Journot
18. ACC – comparison with other cancers

d. Diagnosis

1. Classical Histopathology/Markers Saeger
2. Molecular Pathology Giordano
3. CT/MR diagnosis Mueller/Korobkin/Dunnick
4. Nuclear Medicine localization Avram/Hahner
5. Differentials of Incidentaloma Young/Mantero

e. Therapy

1. Mitotane Berruti
2. Chemotherapy
a. Classical Chemotherapy
b. FIRM-ACT Skogseid
3. Surgical therapy Gauger
4. Radiation Therapy Spalding
5. Retrospective analysis of Tx Fassnacht/Allolio
6. Follow up of ACC patients
7. New Strategies of treatment
a. IGF Ben-Josepg/Hammer
b. Immunological approaches
c. VEGF & Angiogenesis
d. Tyrosine kinase inhibitors Kirschner
e. Radioactive Ligands

f. Models of ACC

1. Cell lines Rainey
2. Mouse models & Xenotransplant Beuschlein
3. Animal models of spontaneous ACC Wilson

g. Special aspects of ACC

1. Steroidogenesis & ACC Rainey
2. Aldosterone producing ACC Rossi/Mantero
3. Cellular origin/identity of ACC (Stem cells)
4. Diagnostic approach to incidentaloma Young
5. Transcrptional regulation in ACC

h. ACC registries

1. German registry Fassnacht
2. European registry Beuschlein/French guy
3. ACC/Tissue banking Beuschlein/Giordano
4. World registry Hammer