Acute Neuronal Injury. the Role of Excitotoxic Programmed Cell Death Mechanisms

About this book

The purpose of this book is to present clinically relevant basic mechanisms of excitotoxic neuronal death, which in the adult mammalian brain is morphologically necrotic, not apoptotic, and which involve caspase-independent mechanisms of programmed cell death.

The spectrum of clinically relevant pathologically induced excitotoxic neuronal death includes cerebral ischemia, traumatic brain injury, cerebral hypoglycemia, and status epilepticus. By investigating mechanisms, potential neuroprotective strategies can be identified that may have future clinical application.

Written for: Neuroscientists and general cell biologists interested in cell death, clinically oriented neuroscientists, including neurologists, neurosurgeons, psychiatrists.

Keywords:

• apoptosis
• caspase-independent mechanisms
• excitotoxicity
• necrosis
• programmed cell death

Table of contents

Preface: Programmed mechanisms and the clinical spectrum of excitotoxic neuronal death,- Introduction: The concept of excitotoxicity: an historical perspective.- Part 1: Programmed cell death.- Part 2: Focal Cerebral ischemia.- Part 3: Transient Global Ischemia.- Part 4: Traumatic brain injury.- Part 5: Hypoglycemic neuronal death.- Part 6: Seizure-induced neuronal death.- Summary and Conclusions.