This issue is a must-read for perinatologists and neonatologists who need current advances in treastment and interventions to improve the viability of the neonate. The Guest Editors have put together a concise monograph on the topic, offering the most current clinica review articles on the following topics: Antenatal corticosteroids: Who should we be treating?; Quality improvement strategies to improve care of women in preterm labor; Delivery at term: when, how, and why?; Detection and prevention of perinatal infection; Current strategies to prevent perinatal HIV transmission; Advances in fetal monitoring and association with outcomes; Relationship between perinatal interventions, the maternal-infant microbiome and neonatal outcomes; Understanding outcomes and couseling families at a periviable gestational age; Therapeutic hypothermia - how can we optimize this therapy to further improve outcomes; Reducing CPAP failure in extremely preterm infants; Optimizing caffeine therapy in preterm infants; Improving uptake of key perinatal interventions using state-wide quality collaboratives; Oxygen therapy in the delivery room: What is the right dose?; and Perinatal white matter injury: prevention and long-term outcomes. Readers will leave with the best evidence they need to improve outcomes.