The Clinical Neurobiology of the Hippocampus, an Integrative View

About this Book

• The first book to explore the role of the hippocampus in a range of clinical disorders, bringing together literature that has hitherto been scattered across a range of publications into one comprehensive reference source
• Features a wide list of renowned specialist authors and experts who cover all the basic and clinical aspects of the hippocampus, resulting in a book that is authoritative and accessible
• Illustrated in full colour to give clarity and aid comprehension

The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical and neurocomputational literature that presents basic mechanisms, theoretical models and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented in current literature, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines.

The Clinical Neurobiology of the Hippocampus explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches.

The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural and psychiatric symptoms and surpasses the ability to encode, store and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia.

The first part of the book covers the basic and integrative features of the hippocampus, such as the anatomy and imaging of this structure, and the basic mechanisms of hippocampal function, including the principles of hippocampus-dependent memory processing in amnesia and sleep, the mechanisms of vulnerability and adult neurogenesis as well as the effects of stress. The second part covers the various clinical manifestations in which the hippocampus is involved and in which the preceding basic mechanisms are reflected.

Bringing together a broad team of experts on the basic and clinical aspects of the hippocampus, the book provides an integrative view of the hippocampus. It is invaluable for neurologists, neuroscientists, and psychiatrists, and will stimulate interdisciplinary discussions in clinical neuroscience.

Readership: Clinical neurologists and neuroscientists, psychiatrists, neuropaediatricians, neuroradiologists, basic scientists, and students

Table of Contents

1. Thorsten Bartsch: Introduction: The Hippocampus in the Clinical Neurosciences
2. Pierre Lavenex: Functional Anatomy, Development, and Pathology of the Hippocampus
3. Howard Eichenbaum: Amnesia and the Hippocampal Memory System
4. Elias K. Michaelis: Selective Neuronal Vulnerability in the Hippocampus: Relationship to Neurological Diseases and Mechanisms for for Differential Sensitivity of Neurons to Stress
5. E. Ronald de Kloet: Stress and the Hippocampus
6. Gerd Kempermann and Alexander Garthe: Adult Hippocampal Neurogenesis: Functional Implications of a 'New' Type of Plasticity
7. Bradford C. Dickerson and Jean C. Augustinack: Imaging the Hippocampus
8. Ariane Foret and Pierre Maquet: Sleep, Memory and the Hippocampus
9. Lan T. Hoang, James P. Lister, and Carol A. Barnes: The Aging Hippocampus
10. Alexander Prehn-Kristensen, Richard Cooke, Lioba Baving, and Cynthia Schumann: Neurodevelopemental Disorders
11. Thorsten Bartsch: The Hippocampus in Neurological Disease
12. Maija Pihlajamäki and Hilkka Soininen: Alzheimer's Disease
13. Radwa A.B. Badawy and Graeme D. Jackson: Temporal Lobe Epilepsy and the Hippocampus
14. J. Douglas Bremner and Eric Vermetten: Hippocampus and Post-Traumatic Disorders
15. Glenda M. MacQueen and Thomas Frodl: The Hippocampus in Major Depression
16. Peter Falkai, Oliver Gruber, and Andrea Schmitt: Schizophrenia

Author Information

Edited by Thorsten Bartsch, Department of Neurology, Consultant Neurologist, Head of the Memory Disorders Group, University Hospital of Schleswig Holstein, Kiel, Germany

Contributors:

Jean C. Augustinack, Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical, School, Boston, USA
Radwa A.B. Badawy, Brain Research Institute, Department of Neurology, Austin Health, Royal Children's Hospital, Melbourne, Australia
Lioba Baving, Department of Child and Adolescent Psychiatry University of Kiel, Kiel, Germany
Carol A. Barnes, ARL Division of Neural Systems, Memory and Aging Psychology and Neurology Life Sciences, University of Arizona, Tucson, AZ, USA
Thorsten Bartsch, Department of Neurology, University of Kiel, Kiel, Germany
J. Douglas Bremner, Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
Richard Cooke, University of Liverpool, School of Reproductive and Developmental Medicine, Liverpool, UK
E. Ronald de Kloet, Faculty of Science, Center for Drug Research Leiden, Amsterdam, The Netherlands
Bradford C. Dickerson, Department of Neurology, MGH Memory Disorders and Frontotemporal Dementias Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Howard Eichenbaum, Center for Memory and Brain, Boston University, Boston, MA, USA
Peter Falkai, Department of Psychiatry, University of Göttingen, Göttingen, Germany
Ariane Foret, Cyclotron Research Centre - Liège University, Liège, Belgium
Thomas Frodl, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
Alexander Garthe, Center for Regenerative Therapies, University of Dresden, Dresden, Germany
Oliver Gruber, Department of Psychiatry, University of Göttingen, Göttingen, Germany
Lan T. Hoang, ARL Division of Neural Systems, Memory and Aging Psychology and Neurology Life Sciences, University of Arizona, Tucson, AZ, USA
Graeme D. Jackson, Brain Research Institute, Department of Neurology, Austin Health, Royal Children's Hospital, Melbourne, Australia
Mathieu Jaspar, Cyclotron Research Centre - Liège University, Liège, Belgium
Gerd Kempermann, Center for Regenerative Therapies, University of Dresden, Dresden, Germany
Caroline Kussé, Cyclotron Research Centre - Liège University, Liège, Belgium
Pierre Lavenex, Laboratory of Brain and Cognitive Development, Department of Medicine/Physiology Fribourg, Switzerland
James P. Lister, ARL Division of Neural Systems, Memory & Aging, University of Arizona, Tucson, AZ
Glenda M. MacQueen, Department of Psychiatry, Faculty of Medicine, University of Calgary, Calgary, Canada
Pierre Maquet, Cyclotron Research Centre, Liège University, Liège, Belgium
Laura Mascetti, Cyclotron Research Centre, Liège University, Liège, Belgium
Luca Matarazzo, Cyclotron Research Centre, Liège University, Liège, Belgium
Elias K. Michaelis, Higuchi Biosciences Center, Department of Pharmacology & Toxicology, University of Kansas, Lawrence, KS, USA
Vincenzo Muto, Cyclotron Research Centre, Liège University, Liège, Belgium
Maija Pihlajamäki, Department of Neurology, University of Eastern Finland, Kuopio, Finland
Alexander Prehn-Kristensen, Department of Child and Adolescent Psychiatry University of Kiel, Kiel, Germany
Andrea Schmitt, Department of Psychiatry, University of Göttingen, Göttingen, Germany
Cynthia Schumann, Psychiatry and Behavioral Sciences, The Medical Investigation of Neurodevelopmental Disorders Institute (M.I.N.D.), Sacramento, CA, USA
Anahita Shaffi i-Le Bourdiec, Cyclotron Research Centre, Liège University, Liège, Belgium
Hilkka Soininen, Institute of Clinical Medicine - Neurology, University of Eastern Finland, School of Medicine, Yliopistonranta, Finland
Eric Vermetten, Military Mental Health/University Medical Center Utrecht, Utrecht, Netherlands