Cognitive Impairment and Dementia in Parkinson's Disease

About this Book

• The first textbook on cognitive impairment and dementia in Parkinson's disease to provide a complete up-to-date reference source on the topic
• All aspects of the disease are covered, giving readers a comprehensive overview of the condition
• Extensive references enable readers to source all relevant literature

Parkinson's disease has long been perceived as a pure motor disorder, partly due to its initial description by James Parkinson, who suggested that "senses and intellect remain intact", and partly due to the fact that patients with PD did not survive long, before effective treatment became available. As the survival time of patients with Parkinson's disease has substantially increased due to modern treatment, it has become apparent that cognitive deficits and dementia are also frequent features, especially in elderly patients. With the progression of the disease and age, dementia develops in a substantial number of patients and constitutes a major therapeutic challenge. Dementia has thus increasingly been the focus of research and practice in recent years and a large body of knowledge has been accumulated. Despite these developments there has been no single volume dedicated to this topic.
This book provides an extensive overview of the current status of knowledge pertaining to cognitive impairment and dementia associated with Parkinson's disease, intended as a reference book for general neurologists, neurology residents and also those with a special interest in movement disorders. In this edited volume experts in the field describe in detail all aspects of cognitive impairment and dementia in Parkinson's disease, including epidemiology, spectrum of clinical features, pathology, neurochemistry and genetics, findings in auxiliary investigations, relation to other neurodegenerative disorders, diagnostic process and management, and rounded up by discussion of future research directions and expectations. The text is complemented and enriched with tables, figures and heavily referenced to encompass all relevant literature.

Readership: This book is designed for neurologists, neurology residents, movement disorder specialists, and neuropsychologists, but will also be of interest to psychiatrists, geriatricians, interested general practitioners, neuroscientists, and specialist nurses.

Reviews

"...this book can also be thoroughly recommended to general neurologists" - The Lancet: Neurology

Table of Contents

1: Murat Emre: Introduction
2: Dag Aarsland: The epidemiology of dementia associated with Parkinson's disease
3: Murat Emre: General features, mode of onset and the course of dementia in Parkinson`s disease
4: Kolbjørn Brønnick: Cognitive profile in Parkinson's disease dementia
5: Daniel Weintraub and Eugenia Mamikonyan: Neuropsychiatric symptoms in Parkinson's disease dementia
6: Paolo Barone and Gabriella Santangelo: The interaction between affect and executive functions in Parkinson's disease
7: David J Burn: Motor symptoms and phenotype in patients with Parkinson's disease dementia
8: JM Hausdorff, G Yogev-Seligman, M Plotnik, A Mirelman, N Giladi: Interaction between cognition and gait in patients with Parkinson's disease
9: Eduardo Tolosa and Alex Iranzo: Disorders of sleep and autonomic function in Parkinson's disease dementia
10: Michael J. Firbank & John T O'Brien: Neuroimaging in Parkinsons' Disease Dementia
11: Yasuyuki Okuma and Yoshikuni Mizuno: Electrophysiological and other auxiliary investigations in patients with Parkinson's disease dementia
12: Rita Guerreiro, Andrew Singleton: The genetic basis of dementia in Parkinson's disease
13: Margaret Ann Piggott and Elaine K Perry: Neurochemical pathology of Parkinson's disease dementia
14: Gonzalo J. Revuelta and Carol Lippa: Pathological correlates of dementia in Parkinson's disease
15: Elise Caccappolo and Karen Marder: Cognitive impairment in non-demented patients with Parkinson's disease
16: Clive Ballard, Dag Aarsland: Spectrum of lewy body dementias: relationship of PD-D to DLB
17: Jaime Kulisevsky and Javier Pagonabarraga: Spectrum of disorders with Parkinsonism and dementia
18: Murat Emre: Diagnosis of dementia in Parkinson's disease
19: Ian McKeith and Murat Emre: Management of Parkinson's disease dementia and dementia with lewy bodies
20: John Hardy: Parkinson's disease: what will the future bring?

Author Information

Edited by Murat Emre, Professor of Neurology, Department of Neurology, Istanbul Faculty of Medicine, Istanbul, Turkey