Deep Brain Stimulation

Description

Deep brain stimulation (DBS) has become the major growth area for the treatment of severe Parkinson's disease, tremors and dystonia over the past 10 years. More recently, interest has begun to focus on the clinical use of DBS for the treatment of psychiatric disorders, particularly obsessive-compulsive disorders and depression. The increasing therapeutic use of DBS has created opportunities to study the pathophysiology of these diseases, by allowing intracerebral recordings to be made from patients and permitting electrical stimulation of various regions within the brain to be undertaken.
This handbook provides an overview of the use of DBS for the treatment of movement disorders as well as an introduction to the developing area of DBS for the management of psychiatric disease. The first part of the book covers the varying surgical techniques involved in implanting electrodes into various deep nuclei within the brain, including the neurophysiological techniques involved in this process and the complex issue of programming the implanted stimulator in order to optimise therapeutic efficacy and minimise stimulation-induced adverse effects. The second part of the book describes how to select appropriate patients for DBS and describes the results of DBS treatment for Parkinson's disease, dystonia and various tremors, as well as psychiatric conditions.

The book is intended to introduce neurologists, trainee neurologists and movement disorder specialists to the topic of DBS and will also prove valuable to nurses specializing in the management of Parkinson's disease and/or movement disorders. The book will also serve as a practical reference for psychiatrists interested in modern psychosurgery and scientists with an interest in DBS, the electrode-brain interface and the pathophysiology and neural circuitry of Parkinson's disease, tremor and dystonia.

Contents

Part 1 - Surgical techniques

1. Subthalamic nucleus stimulation , Alim Benabid, Stephan Chabardes & Jean Francois LeBas
2. Globus pallidus stimulation , Marwan I. Hariz & Ludvic Zrinzo
3. Thalamic stimulation , Hans Speelman, Rob de Bie & Rick Schuurman
4. Zona incerta and Pediculopontine stimulation , Sadaquate Khan, Shazia Javed, Nikunj K. Patel, Puneet Plaha & Steven S. Gill

Part 2 - Operative physiological techniques and post-operative stimulator programming

5. Microelectrode recording , William Hutchison
6. Macroelectrode recording , Andreas Kupsch, Andreas Kühn, Peter Brown
7. Test stimulation , Xuguang Liu
8. DBS stimulator programming , Patricia Limousin & Stephen Tisch

Part 3 - DBS for movement disorders

9. Selecting appropriate Parkinson's patients for DBS , Jens Volkmann
10. The long term results of STN stimulation , W. M. Michael Schüpbach
11. The long term results of GPi stimulation , Alexander L Green, Erlick AC Pereira, Tipu Z Aziz
12. Post-STN DBS Parkinson's disease , Boulos-Paul Bejjani, Mazen Jabre, Jean-Luc Houetto
13. Selecting appropriate dystonic patient for GPi stimulation , Pettarsup M Wadia, Anthony E Lang, Elena Moro
14. The results of GPi stimulation for generalized dystonia , Sean O'Riordan
15. The results of GPi stimulation for focal dystonia , Hans-Holger Capelle, Joachim K. Krauss
16. Selecting appropriate tremor patients for DBS , Alfonso Fasano, Jan Herzog, Gunther Deuschl
17. The results of DBS for tremor , Peter Bain

Part 4 - DBS for psychiatric conditions

18. DBS for Gilles de la Tourette syndrome , Jean-Luc Houeto, Boulos-Paul Bejjani & Nemat Jaafari
19. DBS for obsessive compulsive disorder , Bart Nuttin, Loes Gabriëls, Paul Cosyns, Kris van Kuyck, Marleen Welkenhuysen, Laura Luyten, Dimiter Prodanov, Amina Ahmed & John Das
20. Cingulate area 25 DBS for depression , Brian J Snyder, Clement Hamani, Andreas M Lozano

Part 5 - Mathematical modelling of DBS

21. Modelling approaches to DBS , Nada Yousif & Xuguang Liu
22. Appendix: Useful links

Authors and editors:

Edited by Peter Bain, Reader in Clinical Neurology, Department of Clinical Neuroscience, Imperial College London, UK,
Tipu Aziz, Professor of Neurosurgery, Nuffield Department of Surgery, University of Oxford, UK,
Xuguang Liu, Consultant in Surgical Neurophysiology, Department of Neurosciences, Imperial College London, UK, and
Dipankar Nandi, Consultant Neurosurgeon, Department of Neurosciences, Imperial College Healthcare NHS Trust, London, UK