Molecular Biology of Cancer. Mechanisms, Targets, and Therapeutics

1:Introduction
2:The cancer genome
3:Regulation of gene expression
4:Growth factor signaling and oncogenes
5:The cell cycle
6:Tumor suppressor genes
7:Apoptosis
8:Cancer stem cells and the regulation of self-renewal and differentiation pathways: focus on colon cancer and leukemias
9:Metastasis
10:Angiogenesis
11:Reprogrammed metabolism and diet
12:Tumor immunology and immunotherapy
13:Inflammation, infection, and the microbiome
14:Strategies and tools for research and drug development

Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.

• Provides an engaging and manageable route into the complex subject of cancer biology
• Describes the theoretical basis of cancer biology and shows how this theory is applied to develop new cancer therapies, giving students a clear appreciation of how theoretical knowledge can be translated into therapeutic strategies
• Draws on the latest research in this dynamic field but presents it in a manner readily accessible to the student
• Available for students and institutions to purchase in a variety of formats, and is supported by online resources.

New to this edition

• The inclusion of additional primary data from the literature provides up-to-date information about this dynamic field of research.
• Figures to illustrate mechanisms of DNA repair.
• New topics covered include extrachromosomal circular DNA as major sources of oncogene expression and tumor heterogeneity, the use of errors in RNA transcription and splicing as a new source of neoantigens for vaccines, the application of artificial intelligence to cancer imaging, and expanded applications of CRISPR, to name a few.
• The expanded "Pioneers in the field" feature introduces students to thirteen inspiring molecular biologists working in the field from past to present.

Lauren Pecorino, Professor, Cancer Biology, University of Greenwich
Dr Lauren Pecorino obtained her PhD in Cell and Developmental Biology at the State University of New York at Stony Brook, USA. She then moved to London to carry out a post-doctoral tenure at the Ludwig Institute for Cancer Research where she studied the phenomenon of limb regeneration. Here she used a technique called biolistics, using a 'gene gun' to shoot gold bullets coated with DNA to introduce genes into the regenerating limbs of live newts. Since 1996, Lauren has been a member of academic staff at the University of Greenwich, where she developed her interest in teaching Cancer Biology. In 2018, Lauren was made a Principal Fellow of the Higher Education Academy.