Section 1: The multicellular organism
1: The multicellular organism and cancer, Francesco Pezzella, David Kerr, and Mahvash Tavassoli
2: DNA repair and genome integrity, Giacomo Buscemi
3: Evolution and cancer, Tom Donnem and Francesco Pezzella
Section 2: The etiology of cancer
4: Genetics and genetic instability in cancer, Mark A. Glaire and David N. Church
5: Epigenetics, Edward Hookway, Nicholas Athanasou, and Udo Oppermann
6: Viral carcinogenesis - an overview, Dirk P. Dittmer and Blossom Damania
7: Chemical carcinogens, David H. Phillips
8: Radiation as a Carcinogen, Yan-Qun Xiang and Chao-Nan Qian
Section 3: How the cancer cell works
9: Growth factors and associated signalling pathways in tumour progression and in cancer treatment, Nadège Gaborit and Yosef Yarden
10: Hormones and Cancer, Balkees Abderrahman and V. Craig Jordan
11: Oncogenesis and tumour suppression, Mahvash Tavassoli and Francesco Pezzella
12: The signaling pathways in cancer, Jiangting Hu
13: Cell cycle control, Simon Carr and Nicholas La Thangue
14: Cancer and cell death, Jessica Bullenkamp and Mahvash Tavassoli
15: Telomerase and immortalisation, Laura Collopy and Kazunori Tomita
16: Cancer metabolism, Almut Schulze, Karim Bensaad, and Adrian L Harris
17: Chaperones and protein quality control in the neoplastic process, Andrea Rasola
18: Oxygen and cancer: the response to hypoxia, Adrian L Harris and Margaret Ashcroft
19: Invasion, Metastasis and Tumor Dormancy, Andrey Ugolkov and Andrew P. Mazar
20: Cancer Stem Cells, Connor Sweeney, Lynn Quek, Betty Gration, and Paresh Vyas
Section 4: Cancer microenvironment
21: Cancer associated stroma, W.E. Mesker and R.A.E.M. Tollenaar
22: Blood vessels and cancer, Francesco Pezzella and Robert Kerbel
23: Cancer Immunology, Herman Waldmann
Section 5: Global vision of cancer
24: Molecular profiling in cancer research and personalized medicine, Pieter-Jan van Dam and Steven Van Laere
25: Proteomics and metabolomics applications in cancer biology, Pedro Cutillas and Benedikt M. Kessler
26: Cancer systems biology: from molecular profiles to pathways, signalling networks and therapeutic vulnerabilities, Lieven Verbeke and Steven Van Laere
27: Cancer biology through immunohistology, Karen Pulford and Kevin Gatter
Section 6: The biology of cancer treatment
28: Principles of chemotherapy, David Kerr, Daniel Haller, and Jaap Verweij
29: Immunotherapy and Tumour Resistance to immune mediated control and elimination, Gwennaëlle C. Monnot and Pedro Romero
30: Biological effect of radiotherapy on cancer cells, Anna Dubrovska, Mechthild Krause, and Michael Baumann
Section 7: Conclusions
31: Benign tumours: the forgotten neoplasms, Francesco Pezzella, Adrian L Harris, and Mahvash Tavassoli
32: Conclusions: cancer biology, a moveable feast, David Kerr and Mahvash Tavassoli
The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field.
Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving.
Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.
- Multidisciplinary approach to cancer biology including topics such as genomics, systems biology, proteomics, metabolomics, and digital pathology
- Expert authors and an international team of writers present a truly global view of cancer biology
- Comprehensive yet accessible coverage suitable for scholars, professionals, and practitioners from a wide variety of cancer specialisms
- Many chapters drawn from and designed to complement the third edition of the highly acclaimed Oxford Textbook of Oncology
- Can be read as one complete narrative or as standalone chapters
Edited by Francesco Pezzella, Professor of Tumour Pathology, University of Oxford, UK, Mahvash Tavassoli, Professor of Molecular Oncology, King's College London, UK, and David J. Kerr, Professor of Cancer Medicine, University of Oxford, UK; and Adjunct Professor of Medicine, Weill Cornell College of Medicine, New York, USA.
Francesco Pezzella is Professor of Tumour Pathology at the University of Oxford, UK, and Consultant Pathologist at the Oxford University Hospitals. His early work focused on the pathology of HIV and its effect on lymph nodes, followed by the molecular alterations of non-Hodgkin's Lymphoma. His research then turned to cancer and blood vessels, whereby he discovered the non-angiogenic pathway of the growth of human cancers, leading to a change in one of the hallmarks of cancer. Professor Pezzella continues to specialise in haematopathology and has published over 200 papers.
Mahvash Tavassoli is Professor of Molecular Oncology at King's College London, UK. She has held several positions internationally, including at the Fred Hutchinson Cancer Research Centre in Seattle, the University of Sussex, and the Max Planck institute in Munich. Professor Tavassoli's early research focused on understanding the signaling and apoptosis pathways which are deregulated in cancer, before shifting towards the clinical application of her lab work. She currently leads a research team at KCL focused on developing genetic tests for the early detection and prediction of patient response to radiotherapy in head and neck cancer. They aim to develop more effective, less toxic cancer therapeutics.
David J. Kerr is Professor of Cancer Medicine, at the University of Oxford, UK, and Adjunct Professor of Medicine at Weill Cornell College of Medicine in New York, USA. Professor Kerr has made a sustained and internationally recognised contribution to cancer care and research in the field of medical oncology over the past three decades. He has published over 400 papers in high profile journals, authored over twenty books, and has been awarded four prestigious, international research prizes, including the NHS's first Nye Bevan award for Innovation. His scientific standing has been recognised by election as Fellow of the Royal College of Physicians, Fellow of Academy of Medical Sciences, President of the European Society of Medical Oncology (2009-2011), and Founding Fellow of the European Academy of Cancer Sciences.