Functional Mri. an Introduction to Methods

ABOUT THIS BOOK

This book provides a comprehensive introduction to functional magnetic resonance imaging (fMRI), the scanning
technique which allows the mapping of active processes within the brain.

There are six sections to the book with chapters from an expert international team. Part I provides a broad overview of the field and sets the context. Part II describes the physiological and physical background to fMRI, including coverage of the hardware required and pulse sequence selection. Practical issues involving experimental design of the paradigms, psycho-physical stimulus delivery and subject response are covered in Part III, followed by a comprehensive treatment of data analysis in Part IV. Part V deals with practical applications of the technique in the field of neuroscience and in clinical practice. The final section describes how fMRI can be integrated with other neuro-electromagnetic functional mapping techniques.

Functional Magnetic Resonance Imaging: An Introduction to Methods is written to be accessible to a wide-ranging
audience of research scientists interested in studying how the normal brain works, and clinicians interested in
monitoring disease states and processes.

Readership: Neuroscientists, neurologists, neuropsychologists, clinical psychologists, physiologists, physicists, radiologists and psychiatrists.

AUTHOR INFORMATION

Edited by Peter Jezzard, Head of MR Physics, Paul M Matthews, Director, and Stephen M Smith, Head of Image Analysis, All at the FMRIB Centre, Department of Clinical Neurology, University of Oxford, UK

REVIEWS

"The work . . . does provide a good overview of the complex physics methods. The images . . . are of high quality and a good guide generally for the clinician." - Doctors.net website

TABLE OF CONTENTS

Part I: Introduction
1: Matthews: An introduction to fMRI of the brain

Part II: Physics and Physiology
2: Gjedde: Brain energy metabolism and the physiological basis of the haemodynamic response
3: Jezzard & Clare: Principles of nuclear magnetic resonance and MRI
4: Jones, Brookes & Moonen: Ultra-fast MRI
5: Glover: Hardware for functional MRI
6: Bandettini: Selection of the optimal pulse sequence for functional MRI
7: Menon & Goodyear: Spatial and temporal resolution in fMRI
8: Hoge & Pike: Quantitative measurement using fMRI

Part III: Experimental Design
9: Donaldson & Buckner: Effective paradigm design
10: Savoy: The scanner as a psychophysical laboratory

Part IV: Analysis of Functional Imaging Data
11: Smith: Overview of fMRI analysis
12: Smith: Preparing fMRI data for statistical analysis
13: Brammer: Head motion and its correction
14: Worsley: Statistical analysis of activation images
15: Jenkinson & Smith: Registration, brain atlases and cortical flattening
16: Buchel & Friston: Extracting brain connectivity

Part V: fMRI Applications
17: Owen, Epstein & Johnsrude: fMRI applications in cognitive neuroscience
18: Thulborn & Gisbert: Clinical applications of mapping neurocognitive processes in the human brain with fMRI

Part VI: Integrating Technologies
19: George, Schmidt, Rector & Wood: Dynamic functional neuroimaging integrating multiple modalities