Introduction to the Cellular and Molecular Biology of Cancer

Great breadth of coverage in one volume: covers all aspects of cancer, in a concise and affordable format
Provides a comprehensive introduction to the initiation, development, and treatment of cancer
Chapter are written by experts in each field, giving a state-of-the-art summary of each topic
Extensive references provide links to all the relevant literature, facilitating further study
New to this edition

This edition has undergone major changes to reflect rapid progress and new developments. Eight new chapters have been added, including coverage of DNA repair, epigenetic events, the cell cycle, cell immortalisation, apoptosis, angiogenesis, animal models, the genome, transcriptome and proteome, radiotherapy and molecular radiotherapy, immunotherapy, and gene therapy. All the material from the previous edition has been extensively revised and new authors have contributed to some chapters.
This new edition of Introduction to the Cellular and Molecular Biology of Cancer provides a concise yet comprehensive overview of cancer biology, covering the current status of both research and treatment. For the student or new researcher the breadth of cancer research can appear daunting, yet a broad understanding is essential for translation of laboratory findings into the clinic. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field, and the accompanying bibliographies allow rapid access to the relevant current literature. The book covers topics extending from the molecular alterations found in cancer cells and their causes to the current range of approaches to treatment. Since the publication of the previous edition in 1997 there has been unprecedented progress in cancer research: this is reflected by an extensive revision of all the material, and the addition of eight new chapters, covering DNA repair, epigenetic events, the cell cycle, cell immortalisation, apoptosis, angiogenesis, animal models, the genome, transcriptome and proteome, radiotherapy and molecular radiotherapy, immunotherapy, and gene therapy. The fourth edition of this popular book will serve as a text for both undergraduate and postgraduate use and also as an introduction for clinicians and scientists new to the field.

Contents

1 L.M. Franks and Margaret A. Knowles: What is cancer?
2 Naomi Allen, Robert Newton, Amy Berrington de Gonzalez, Jane Green, Emily Banks, and Timothy J. Key: The causes of cancer
3 D. Timothy Bishop: Inherited susceptibility to cancer
4 Beate Köberle, John P. Wittschieben, and Richard D. Wood: DNA repair and cancer
5 Jonathan C. Cheng and Peter A. Jones: Epigenetic events in cancer
6 Denise Sheer and Janet Shipley: Molecular cytogenetics of cancer
7 Margaret A. Knowles: Oncogenes
8 Sonia Lain and David P. Lane: Tumour suppressor genes
9 Chris J. Norbury: The cancer cell cycle
10 Robert F. Newbold: Cellular immortalization and telomerase activation in cancer
11 Sally A. Prigent: Growth factors and their signalling pathways in cancer
12 Dean A. Fennell: Apoptosis: molecular physiology and significance for cancer therapeutics
13 Paul Farrell: Mechanisms of viral carcinogenesis
14 Peter W. Szlosarek and Frances R. Balkwill: Cytokines and cancer
15 Charlotte L. Bevan: Hormones and cancer
16 Ian Hart: The spread of tumours
17 K.Tahtis and R.Bicknell: Angiogenesis
18 Mel Greaves: Stem cells, heamopoiesis, and leukaemia
19 Jos Jonkers and Anton Berns: Animal models of cancer
20 Peter C. L. Beverley: The immunology of cancer
21 Tatjana Crnogorac-Jurcevic, Richard Poulsom, and Nicholas R. Lemoine: The molecular pathology of cancer
22 Silvana Debernardi, Rachel Craven, Bryan D. Young, and Rosamonde E. Banks: From transcriptome to proteome
23 Ian S. Fentiman: Local treatment of cancer
24 D.R. Camidge and D.I. Jodrell: Chemotherapy
25 Anne Kiltie: Radiotherapy and molecular radiotherapy
26 T. Geldart, M.J. Glennie, and P.W.M. Johnson: Monoclonal antibodies and therapy
27 Andrew M. Jackson and Joanne Porte: Immunotherapy of cancer
28 John David Chester: Cancer gene therapy
29 Peter Sasieni and Jack Cuzick: Screening
30 Peter Selby and Margaret A Knowles: Conclusions and prospects