Neuropathic Pain. A Case-Based Approach to Practical Management

Part I: Overview of Neuropathic Pain
1. Concept and Overview of Neuropathic Pain
Jianguo Cheng
2. Classification of Neuropathic Pain
Abdullah Kandil and Danielle Perret
3. Mechanisms of Neuropathic Pain
Jianguo Cheng
4. Assessment and Diagnosis of Neuropathic Pain
Erik C. Hustak
5. Nonpharmacological Treatment of Neuropathic Pain
Ravi Mirpuri and Danielle Perret
6. Pharmacological Treatment of Neuropathic Pain
Randall Brewer, Rinoo Shah, and Elizabeth Casserly
7. Interventional Treatment of Neuropathic Pain
Jiang Wu and Jianguo Cheng
8. Surgical Treatment of Neuropathic Pain
Jianguo Cheng and Wenbao Wang
9. Post-Surgical Neuralgia
John P. Kenny IV and Dalia Elmofty
10. Post-Tramatic Neuralgia
Magdalena Anitescu, Joshua Frenkel, and Bradley A. Silva

Part II: Focal or Multifocal Lesions of the Peripheral Nervous System
11. Herpes Zoster and Postherpetic Neuralgia
Jianguo Cheng
12. Entrapment Syndromes
Jonathan P. Eskander, Zeeshan Malik, and Rinoo V. Shah
13. Neurotrauma
John Blackburn and Alexander Bautista
14. Stump Pain
Jagan Devarajan and Beth Minzter
15. Ischemic Neuropathy
Jagan Devarajan and Beth Minzter

Part III: Focal or Multifocal Lesions of the Peripheral Nervous System
16. Diabetic Peripheral Neuropathy
Maximilian Hsia-Kiung
17. HIV Polyneuropathy
Hersimren Basi
18. Immune Related Neuropathy
Whit Braddy
19. Metabolic, Endocrine, and Other Toxic Neuropathies
Martin J. Carney, Preya K. Jhita, Harold J. Campbell, Michelle St. Robin, Mark Motejunas, and Alan D. Kaye

Part IV: Lesions of the CNS
20. Spinal Cord Injury
Justin F. Averna, Alexander Bautista, George C. Chang Cien, and Michael Saulino
21. Brain Infarction (thalamus and brainstem)
Theodore G. Eckman and Jianguo Cheng
22. Spinal Cord Infarction
Randall P. Brewer, Sai Munampalli, and Aliza Kumpinsky
23. Syringomyella
Ashwin Varma, Timothy Bednar, and Gulshan Doulatram
24. Multiple Sclerosis
Samuel W. Samuel and Jianguo Cheng
25. Phantom Pain
Jagan Devarajan and Beth Minzter
26. Cervical Radiculopathy
Samuel W. Samuel and Eduardo E. Icaza

Part V: Spinal Nerve Root Disease: Radicular Pain
27. Thoracic Radicular Pain
Victor Foorsov and Sarah Pastoriza
28. Lumbar Radicular Pain
Varun Rimmalapudi and Radhika Grandhe
29. Arachnoiditis
Zeehsan Malik, Shilpadevi Patil, Sailesh Arulkumar, and Rinoo Shah
30. Trigeminal Neuralgia
Radhika Grandhe, Eli Johnson Harris, and Eugene Koshkin
31. Glossopharyngeal Neuralgia
George C. Chang Chien, Andrea M. Trescot, and Agnes R. Stogicza

Part VI: Neuropathic Pain of the Head and Neck
32. Persistent Idiopathic Facial Pain
Trevor Van Oostrom
33. Occipital Neuralgia
Amin Deroee and Jianguo Cheng
34. Complex Regional Pain Syndrome
Brian A. Kim and Timothy Furnish

Neuropathic pain is one of the most common, most debilitating, most costly, and most difficult to treat categories of chronic pain conditions that are characterized by a lesion or disease of the somatosensory nervous system. Managing neuropathic pain is challenging and requires skillful assessment and comprehensive and integrated treatment strategies that are mechanism-guided, evidence-based, and individualized. However, these critical and integral elements are very fragmented in the current literature. The mechanistic understanding of neuropathic pain is typically found in basic research articles. Clinical research evidence is presented in forms of clinical trials with emphasis on minimizing biases such as those from patient selection and assessment. Individualized considerations for each patient are usually presented in case reports and problem-based learning discussions. 

This book overcomes these barriers and integrates all the critical elements around individual patient care into a coherent management strategy that is practical and applicable to daily clinical practice. Rather than compiling what have been published in the literature, this work emphasizes on identifying and highlighting the key points or findings that guide decision-making in clinical practice. It integrates the key points around a typical case scenario that not only represents the core of the diagnostic and therapeutic processes but also allows introduction and differentiation of painful conditions that bare similarities with the case in hand. The overarching goal is to improve clinical outcomes through better understanding of the mechanisms, more accurate diagnosis, and wiser and more comprehensive treatment strategies.

• Utilizes a case-based learning approach
• Provides guiding questions, and captures key points about mechanisms, diagnosis, and treatment strategies
• Emphasizes the multidisciplinary nature of neuropathic pain and comprehensive therapeutic options and strategies

Jianguo Cheng, MD, PhD, is Professor of Anesthesiology and Director of the Cleveland Clinic Multidisciplinary Pain Medicine Fellowship Program. Dr. Cheng is the President of American Academy of Pain Medicine (AAPM) and immediate past Chair of the US Section of World Institute of Pain. He has recently been appointed to the US Department of Health and Human Services (HHS) Pain Management Best Practices Inter-agency Task Force (PMTF). Dr. Cheng is also a member of the Centers for Medicare & Medicaid Services (CMS) Expert Work Group (EWG). As a clinician, Dr. Cheng was recognized by Best Doctors in America (Best Doctors Inc.), 70 Best Pain Management Physicians in the US (Becker's ASC Review), and Top Doctors (International Association of Anesthesiologists). He has published more than 250 articles including investigations on opioid tolerance and neuropathic pain and a textbook <"Fundamentals of Pain Medicine>" (Springer-Nature). In addition, Dr. Cheng plays active leadership roles in the Association of University Anesthesiologists (AUA), American Board of Anesthesiology (ABA), American Society of Anesthesiologists (ASA), and American Academy of Regenerative Medicine. He also serves as Senior Editor, Associate Editor, and Section Editor for the scientific journals of Pain Medicine, Pain Practice, and Pain Physician.