The Hippocampus Book

Chapter 1: Introduction: The Hippocampal Formation - the Editors
Chapter 2: Historical Perspective - the Editors
Chapter 3: Neuroanatomy - David Amaral, Pierre Lavenex, and Ricardo Insausti
Chapter 4: Development of the Hippocampus - Pierre Lavenex, David Amaral, Pamela Banta Lavenex, Francois Guillemot, Ricardo Insausti, and Noelia Urban
Chapter 5: Cell Properties - Nelsonn Spruston Rebecca Piskorowski, Viven Chevaleyre, Mark D. Eyre, Chris McBain, and Marlene Bartos
Chapter 6: Synaptic Function - Dimitri Kullman and Kirill Volynski
Chapter 7: Local Circuits - Andres D. Grosmark, Aaron D. Milstein, Attila Losonczy, and Ivan Soltesz
Chapter 8: Molecular Mechanisms of Synaptic Function in the Hippocampus - Paul G Donlin-Asp, Anne-Sophie Hafner, and Erin M Schuman
Chapter 9: Structural Plasticity - Rusty Gage, Matthew Shtrahman, Sarah Parylak, and Tomohisa Toda
Chapter 10: Synaptic Plasticity in the Hippocampus - Tim Bliss, Graham Collingridge, Sam Cooke, John Georgiou, and Richard Morris
Chapter 11: Hippocampal Physiology - Julia Krupic and John O'Keefe
Chapter 12: The Entorhinal Cortex - Benjamin R. Kanter, Edvard I. Moser, and Menno P. Witter
Chapter 13: Functions of the Human Hippocampus - Daniel N. Barry and Eleanor A. Maguire
Chapter 14: Theories of Hippocampal Function - Sam Mackenzie, Francesco Gobbo, and Richard Morris
Chapter 15: Aging and the Hippocampus - Sara N. Burke and Carol Barnes
Chapter 16: Computational Models of Hippocampal Cognitive Function - Daniel Bush and Neil Burgess
Chapter 17: Stress and the Hippocampus - Bruce McEwen with Sumantra Chatterji
Chapter 18: Mesial Temporal Lobe Epilepsy - Matthew C. Walker, Maria Thom, and Umesh Vivekananda
Chapter 19: Psychosis and the Hippocampus: Fundamental Alterations in Hippocampal Function - Carol Tamminga, Daniel Scott, and Elena I. Ivleva
Chapter 20: Alzheimer Disease - Dennis Chan, Tara Spires-Jones, Frank Provenzano, Lizzie Glennon, and Karen Duff

PREVIEW THIS BOOK

• Written by world experts on the hippocampus, including two Nobel Laureates, and four winners of The Brain Prize
• Comprehensive update on the astonishing developments in our understanding of hippocampal formation and serves as an essential text in the neuroscience field
• Offers a unique link between neurobiological studies of normal hippocampal function and relevant brain disorders

Long known to be important for memory, the hippocampus has been a prime focus for neuroscience research for years. This second edition of The Hippocampus Book highlights advances in our understanding of this group of brain structures and includes a new set of translational chapters concerning associated brain disorders. This edition brings together contributions by leading international experts on hippocampal anatomy, physiology, molecular biology and function with other chapters summarizing how disorders of hippocampal function contribute to several neurologic and psychiatric conditions.

Concurrently, this text illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, neural and synaptic plasticity, cognition and behaviour, and computational algorithms. Covering theory, experimental data and translational relevance, this uniquely authoritative work vividly illustrates the progress that continues to be made in unravelling the workings of the brain. The Hippocampus Book will be of interest to those working in a range of neuroscientific disciplines, ranging from the molecular biology of neural function and dysfunction, through network physiology to behavior and neuropathology and take pride of place on the bookshelves of all with an interest in the brain and its functions.

Edited by Richard Morris, Professor of Neuroscience, University of Edinburgh, Edited by David G. Amaral, Distinguished Professor of Psychiatry and Neuroscience, University of California, Davis, Edited by Tim Bliss, Group Leader Emeritus, Francis Crick Institute, London, Edited by Karen Duff, Centre Director, UK Dementia Research Institute, University College London, and Edited by John O'Keefe, Professor of Cognitive Neuroscience, Sainsbury Wellcome Centre, University College London

Richard Morris, DPhil, is Professor of Neuroscience at the University of Edinburgh. He is the co-founder of Edinburgh Neuroscience and served as the Head of Neuroscience and Mental Health at the Wellcome Trust where he helped establish the Sainsbury-Wellcome Centre for Neural Circuits and Behaviour. He is a Fellow of the Royal Society and, in 2020, became an international member of the US National Academy of Sciences.

David G. Amaral, PhD, is Distinguished Professor of Psychiatry and Neuroscience at the University of California, Davis. He has studied the neuroanatomical organization and function of medial temporal lobe structures including the hippocampal formation and amygdaloid complex, and has used MRI and behavioral techiques to study children with autism. He is Editor-in-Chief of Autism Research. In 2019, Dr. Amaral was elected to the US National Academy of Medicine.

Tim Bliss, PhD, is a Group Leader Emeritus at the Francis Crick Institute, London. He is the former head of the Division of Neurophysiology at the MRC National Institute for Medical Research in Mill Hill, London from 1967-2006. His work with Terje Lømo provided the first full description of long-term synaptic potentiation (LTP). He is a Fellow of the Royal Society and was a co-recipient of the Greta Lundbeck Brain Prize with Graham Collingridge and fellow editor Richard Morris for their work on synaptic plasticity.

John O'Keefe, PhD, is a Professor at the Sainsbury Wellcome Centre for Neural Circuits and Behaviour and the Department of Cell and Developmental Biology at University College London. He was co-recipient of the Nobel Prize in Physiology or Medicine in 2014 for his discovery of place cells in the hippocampus, important for spatial navigation and the determination of physical position in mammals.

Karen Duff, PhD, is the Centre Director of the UK Dementia Research Institute at University College London. She has developed several important mouse models for Alzheimer's disease and FTD tauopathies which are used extensively for mechanistic and translational studies. She was awarded the Potamkin Prize in 2006 and is a Fellow of the Academy of Medical Sciences.