Diagnostic Molecular Pathology. A Guide to Applied Molecular Testing

Tabla de contenidos

• Section 1 – Introduction to Molecular Testing
  • 1. Introduction to Molecular Testing in Human Disease – William B. Coleman, Ph.D., and Gregory J. Tsongalis, Ph.D.
  • 2. The Polymerase Chain Reaction and Other Amplification Methodologies – William B. Coleman, Ph.D., and Gregory J. Tsongalis, Ph.D.
  • 3. Whole-exome and Whole Genome Sequencing in the Molecular Diagnostic Laboratory – Wahab A. Khan, Ph.D.
  • 4. Long-read Sequencing – Robert Hamilton, M.D., and Samantha Stephen, D.O.
• Section 2 – Molecular Testing in Infectious Disease
  • 5. Molecular Testing for Human Immunodeficiency Virus
  • 6. Molecular Testing in Hepatitis Virus-related Disease
  • 7. Molecular Testing for Human Papilloma Viruses
  • 8. Molecular Testing for Parvoviruses
  • 9. Molecular Testing for Polyomaviruses
  • 10. Molecular Testing for Respiratory Viruses
  • 11. Molecular Testing for Diseases Associated with Bacterial Infection
  • 12. Agents Associated with Sexually-transmitted Infections
  • 13. Molecular Methods for Healthcare-Acquired Infections
  • 14. Molecular Testing in Emerging Infectious Diseases
  • 15. Molecular and Serological Testing in the Setting of a Global Pandemic
• Section 3 – Molecular Testing in Genetic Disease
  • 16. Non-invasive Prenatal Screening (NIPS) for Fetal Aneuploidies
  • 17. Molecular Testing in Cardiomyopathies
  • 18. Molecular Diagnostics for Coagulopathies
  • 19. Molecular Diagnosis of Cystic Fibrosis
  • 20. Molecular Testing in Hemochromatosis
  • 21. Molecular Testing for Spinal Muscular Atrophy
  • 22. Molecular Testing for Autism Spectrum Disorders
• Section 4 – Molecular Testing in Oncology
  • 23. Molecular Testing in Breast Cancer
  • 24. Molecular Testing in Lung Cancer
  • 25. Molecular Testing in Colorectal Cancer
  • 26. Molecular Pathology and Testing in Melanocytic Tumors
  • 27. Molecular Testing for Glioblastoma
  • 28. Molecular Testing in Pancreatic Cancer
  • 29. Molecular Testing in Gynecologic Cancer
  • 30. The Emerging Genetic Landscape in Renal Cell Carcinoma
  • 31. Molecular Testing in Thyroid Cancer
  • 32. Molecular Testing for Pediatric Cancers
  • 33. Molecular Pathogenesis of Soft Tissue and Bone Tumors
  • 34. Molecular Pathology of Gastrointestinal Stromal Tumors
  • 35. Molecular Pathology of Liver Cancer
• Section 5 – Molecular Testing in Hematopathology
  • 36. Molecular Testing in Myeloproliferative Neoplasms
  • 37. Molecular Testing in Myelodysplastic Syndromes
  • 38. Molecular Testing in Acute Myeloid Leukemia
  • 39. Molecular Testing in the Assessment of Bone Marrow Transplant Engraftment
• Section 6 – Molecular Testing in Personalized Medicine
  • 40. Pharmacogenomics in Cardiovascular Disease
  • 41. Personalized Medicine for Disorders of Hemostasis and Thrombosis
  • 42. Personalized Medicine in Cancer Treatment
• Section 7 – The Future of Molecular Testing
  • 43. Imaging Mass Spectroscopy in Clinical Pathology
  • 44. Artificial Intelligence and Deep Learning in Molecular Testing
  • 45. Nanotechnology in Molecular Diagnostics
  • 46. Chip-based Nanotechnology in the Molecular Pathology Laboratory and Beyond
  • 47. Translational and Clinical Applications of the GeoMx® Digital Spatial Profiling Platform

Description

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes, and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis, and prognosis.

The book explains how molecular tests are utilized in the treatment of patients within the framework of personalized medicine, highlights new technologies and approaches in applied molecular pathology, and discusses how discovery-based research yields new and clinically useful biomarkers and diagnostic tests.

As it is essential to stay up to date on new molecular diagnostics in this rapidly changing field, this volume covers critically important areas in the practice of personalized medicine and reflects current understanding of the pathology, pathogenesis, and pathophysiology of human disease.

• Includes new material on mass spectrometry for infectious diseases, microbiome analysis, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more.
• Provides insights into the value of molecular testing compared with traditional methods, including advantages in speed, precision, sensitivity, and overall clinical impact for the patient.
• Focuses on the range of molecular diagnostic tests available in modern molecular pathology and clinical laboratories that can be applied to disease detection, diagnosis, and classification during the clinical workup of patients.
• Explains how molecular tests are used to guide patient treatment in personalized medicine (guided therapies) and for disease prognostication.