Fundamentals of Toxicologic Pathology

1. Overview of Toxicological Pathology

Part I: Principles of Toxicologic Pathology

2. Biochemical and Molecular Basis of Toxicity

3. Pharmacokinetics & Toxicokinetics

4. Principles of Pharmacodynamics & Toxicodynamics

5. Morphologic Manifesations of Toxic Cell Injury

6. Carcinogenesis: Mechanisms and Manifestation

7. Design of Studies & Risk Management in Toxicologic Pathology

Part II: Systems Toxicologic Pathology

8. Hepatobiliary System

9. Cardiovascular System

10. Muscular System

11. Urinary System

12. Immune System

13. Hematopoietic System

14. Respiratory Tract

15. Digestive Tract

16. Exocrine Pancreas

17. Male Reproductive System

18. Female Reproductive System

19. Mammary Gland

20. Endocrine System

21. Nervous System

22. Special Senses: Ocular Sytem

22b. Special Senses: Auditory System

23. Skeletal System (Bone & Joint)

24. Integumentary System

25. Embryo, Fetus & Placenta

Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development.

The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others.

• Presents revised and updated information for each chapter on systems
• Contains expanded sections on applied toxicologic pathology
• Includes the essential information necessary to understand toxicologic pathology in an accessible language