Osteoporosis, 2 Vols.

Osteoporosis is a disease in which the amount of bone mass significantly decreases over a period of time. Because of the decreased bone mass in patients with osteoporosis, painful fractures occur, often caused by what would normally be a mild trauma. Doctors are searching for a way to rectify this by identifying treatments and therapies that can help prevent further bone loss and rebuild the bone that has been depleted.  
 
This Second Edition of the authoritative text in the field gives an objective treatment of all relevant aspects of osteoporosis. Topics covered include basic biology, anatomy, physiology, pathophysiology, preclinical issues, experimental medicine, management, and therapeutics. Written by renowned experts in this field, this book is a must-have for the researcher, the academic clinician, or anyone in the field of bone biology.  

Reviews
 
Praise for the First Edition  
 
"...interesting, comprehensive and up-to-date: each chapter has something new and important to say...Whichever direction one chooses to approach this monumental work I predict it will be worthwhile"  
-Journal of Bone and Joint Surgery  
 
"...a textbook focused solely on this condition and encompassing this diversity of research has been lacking. This book does a terrific job of filling the gap. It contains 70 chapters grouped in six sections...All the chapters are authoritative and include up-to-date references...Osteoporosis is quite comprehensive; indeed, topics that typically receive brief treatment elsewhere (osteoporosis in minority groups and in men) receive entire chapters here...The book also covers relevant methodologic concepts, no doubt reflecting the editors desire to make the material accessible to readers with other primary research interests." -THE NEW ENGLAND JOURNAL OF MEDICINE  

Features

• Approximately 30% new material
• Each chapter has been updated or revised
• Broad coverage of the topic
• Well illustrated chapters
• Each chapter written by experts in their fields 

Contents

 
Contributors 
Preface 
 
VOLUME 1  Part I Introduction to Normal Bone Physiology and Pathophysiology  
 
Chapter 1 The Bone Organ System: Form and Function  
Cassandra A. Lee and Thomas A. Einhorn  
 
Chapter 2 Osteoblast Biology  
Jane B. Lian and Gary S. Stein  
 
Chapter 3 Osteoclast Biology  
F. Patrick Ross and Steven L. Teitelbaum  
 
Chapter 4 The Biochemistry of Bone  
Jayashree A. Gokhale, Pamela Gehron Robey, and Adele L. Boskey  
 
Chapter 5 Developmental Biology of Bone  
Anthony M. Reginato, Wenfang Wang, and Bjorn R. Olsen  
 
Chapter 6 Mouse Genetics as a Tool to Study Bone Development and Physiology  
Millan S. Patel and Gerard Karsenty  
 
Chapter 7 Parathyroid Hormone and Parathyroid Hormone-Related Protein  
Robert A. Nissenson  
 
Chapter 8 Calcitonin  
Ana O. Hoff, Gilbert J. Cote, and Robert F. Gagel  
 
Chapter 9 Vitamin D: Biology, Action, and Clinical Implication  
David Feldman, Peter J. Malloy, and Coleman Gross  
 
Chapter 10 Regulation of Bone Cell Function by Estrogens  
Barry S. Komm and Peter V. N. Bodine  
 
Chapter 11 Skeletal Biology of Androgens  
Kristine M. Wiren and Eric S. Orwoll  
 
Chapter 12 Coupling of Bone Resorption and Formation during Bone Remodeling  
Thomas J. Martin and Gideon A. Rodan  
 
Chapter 13 Cytokines and Bone Remodeling  
Gregory R. Mundy, Babatunde Oyajobi, Kathy Traianedes, Sarah Dallas, and Di Chen  
 
Chapter 14 Bone Growth Factors  
Xuezhong Qin, Reinhard Gysin, Subburaman Mohan, and David J. Baylink  
 
Chapter 15 Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the Understanding of Osteoporosis  
A. M. Parfitt  
 
Chapter 16 Basic Biology of Bisphosphonates  
H. Fleisch  
 
Part II Structure and Biomechanics  
 
Chapter 17 Skeletal Development: Mechanical Consequences of Growth, Aging, and Disease  
Marjolein C. H. van der Meulen, Dennis R. Carter, and Gary S. Beaupr�  
 
Chapter 18 Inhibition of Osteopenia by Biophysical Intervention  
Clinton T. Rubin and Kenneth J. McLeod  
 
Chapter 19 Biomechanics of Age-Related Fractures  
Mary L. Bouxsein  
 
Part III Epidemiology and Risk Factors  
 
Chapter 20 Introduction to Epidemiologic Methods  
Jennifer L. Kelsey and MaryFran Sowers  
 
Chapter 21 Magnitude and Impact of Osteoporosis and Fractures  
L. Joseph Melton III and Cyrus Cooper  
 
Chapter 22 Race, Ethnicity, and Osteoporosis  
Marie Luz Villa, Lorene Nelson, and Dorothy Nelson  
 
Chapter 23 Epidemiology of Osteoporosis Fractures: The European Experience  
Chris de Laet and Jonathan Reeve  
 
Chapter 24 Bone Mineral Acquisition in Utero , during Infancy, and throughout Childhood  
Bonny Specker, Ran Namgung, and Reggie C. Tsang  
 
Chapter 25 Bone Acquisition in Adolescence  
Jean-Philippe Bonjour and Rene Rizzoli  
 
Chapter 26 Genetics and Genomics of Osteoporosis  
Andr� G. Uitterlinden, Johannes P. T. M. van Leeuwen, and Huibert A. P. Pols  
 
Chapter 27 Nutrition and Risk for Osteoporosis  
Robert P. Heaney  
 
Chapter 28 Physical Activity and Osteoporosis  
Belinda R. Beck, Janet Shaw, and Christine M. Snow  
 
Chapter 29 Premenopausal Reproduction and Hormonal Characteristics and Risk for Osteoporosis  
MaryFran Sowers  
 
Chapter 30 Postmenopausal Endogenous and Exogenous Hormones, Degree of Obesity, Thiazide Diuretics, and Risk of Osteoporosis  
Jane A. Cauley and Loran M. Salamone  
 
Chapter 31 The Effects of Tobacco and Alcohol Use on Bone  
Ego Seeman  
 
Chapter 32 Falls as Risk Factors for Fractures  
Anne Schwartz, Elizabeth Capezuti, and Jeane Ann Grisso  
 
Chapter 33 Assessing Fracture Risk  
Charles W. Slemenda, C. Conrad Johnston, and Siu L. Hui  
 
Chapter 34 Outcomes of Osteoporotic Fractures  
Elizabeth Barrett-Conner and Gail Greendale  
 
VOLUME 2  Part IV Pathophysiology  
 
Chapter 35 The Nature of Osteoporosis  
Robert Marcus and Sharmilla Majumder  
 
Chapter 36 Local and Systemic Factors in the Pathogenesis of Osteoporosis  
Lawrence R. Raisz  
 
Chapter 37 Animal Models for in Vivo Experimentation in Osteoporosis Research  
Donald B. Kimmel  
 
Chapter 38 The TypeI/Type II Model for Involutional Osteoporosis: Update and Modification Based on New Observations  
B. Lawrence Riggs, Sundeep Khosla, and L. Joseph Melton III  
 
Chapter 39 Bone Remodeling Findings in Osteoporosis  
Robert R. Recker and M. Janet Barger-Lux  
 
Chapter 40 The Role of Parathyroid Hormone and Vitamin D in the Pathogenesis of Osteoporosis  
John P. Bilezikian and Shonni J. Silverberg  
 
Chapter 41 Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss  
Roberto Pacifici  
 
Chapter 42 Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization  
Eric S. Orwoll and Robert F. Klein  
 
Chapter 43 Osteoporosis in Childhood and Adolescence  
Laura K. Bachrach  
 
Chapter 44 Glucocorticoid-Induced Osteoporosis: Basic Pathological Mechanisms, Clinical Features, and Management in the New Millennium  
Gary M. Leong, Jacqueline R. Center, N. Kathryn Henderson, and John A. Eisman  
 
Chapter 45 Familial Osteoporosis  
Alan L. Burshell and Steven R. Smith  
 
Chapter 46 Immobilization Osteopenia  
B. Jenny Kiratli  
 
Chapter 47 Thyroid Hormone and the Skeleton  
Daniel Baran  
 
Chapter 48 Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Diseases  
Daniel D. Bikle  
 
Chapter 49 Primary Hyperparathyroidism and Hyperparathyroid Bone Disease  
Lorraine A. Fitzpatrick and Hunter Heath III  
 
Chapter 50 Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis  
Jay R. Shapiro  
 
Chapter 51 Osteoporosis Secondary to Illnesses and Medications  
Adina Schneider and Elizabeth Shane  
 
Chapter 52 Transplantation Osteoporosis  
Sol Epstein and Elizabeth Shane  
 
Chapter 53 Osteoporosis Associated with Pregnancy  
Lynn Kohlmeier and Robert Marcus  
 
Chapter 54 Osteoprosis Associated with Rheumatologic Disorders  
Steven R. Goldring  
 
Chapter 55 Oral Bone Loss and Systemic Osteopenia  
Marjorie K. Jeffcoat, Michael S. Reddy, and Arthur A. Decarlo  
 
Part V Evaluation and Management  
 
Chapter 56 Localized Osteoporosis  
D. J. Schurman, W. J. Maloney, and R. L. Smith  
 
Chapter 57 The Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis  
Michael Kleerekoper  
 
Chapter 58 Imaging of Osteoporosis  
Michael Jergas and Harry K. Genant  
 
Chapter 59 Clinical Use of Bone Densitometry  
Kenneth G. Faulkner  
 
Chapter 60 Biochemical Markers of Bone Turnover in Osteoporosis  
P. Garnero and P. D. Delmas  
 
Chapter 61 Osteoporosis and Its Nonskeletal Consequences: Their Impact on Treatment Decisions  
Deborah T. Gold, Kenneth W. Lyles, Kathy M. Shipp, and Marc K. Drezner  
 
Chapter 62 An Orthopedic Perspective of Osteoporosis  
Michael H. Heggeness and Kenneth B. Mathis  
 
Chapter 63 Clinical Use of Bone Biopsy  
P. Chavassieux, M. Arlot, and P. J. Meunier  
 
Part VI Pharmacology and Therapeutics  
 
Chapter 64 Design Considerations for Clinical Investigations of Osteoporosis  
Robert P. Heaney  
 
Chapter 65 Development and Evaluation of New Drugs for Osteoporosis  
Henry Bone  
 
Chapter 66 Evidence-Based Decision Making in Osteoporosis  
Ann B. Cranney and Gordon H. Guyatt  
 
Chapter 67 The Role of Calcium in the Treatment of Osteoporosis  
Bess Dawson-Hughes  
 
Chapter 68 Vitamin D and Its Metabolites in the Management of Osteoporosis  
Ian R. Reid  
 
Chapter 69 Estrogens and Osteoporosis  
Robert Lindsay and Felicia Cosman  
 
Chapter 70 Selective Estrogen Receptor Modulators (SERMs)  
Ethel S. Siris and Douglas B. Muchmore  
 
Chapter 71 Phytoestrogen and Other Phytochemical Effects on Bone  
Richard Prince  
 
Chapter 72 Bisphosphonates in the Management of Postmenopausal Osteoporosis  
Socrates E. Papapoulous  
 
Chapter 73 Calcitonin  
Roberto Civitelli  
 
Chapter 74 Fluoride Therapy for Osteoporosis  
K.-H. William Lau and David J. Baylink  
 
Chapter 75 A New Perspective on Fluoride Therapy  
Charles Y. C. Pak  
 
Chapter 76 Androgens and Andogenic Progestins  
Sundeep Khosla  
 
Chapter 77 Treatment with PTH Peptides  
Lis Mosekilde and Jonathan Reeve  
 
Chapter 78 Growth Hormone and Insulin-Like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis  
Christian W�ster and Clifford Rosen  
 
Chapter 79 New Approaches to Osteoporosis Therapeutics  
S. Aubrey Stoch, Michael Chorev, and Michael Rosenblatt  
 
Index