Progress in Molecular Biology and Translational Science, Vol. 109: The Proteasomal System in Aging and Disease

Description

This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease.

Table of Contents

1. Structure of the Proteasome
   Tobias Jung and Tilman Grune
2. Structure and Function of the Ubiquitin-Proteasome System: Modulation of Components
   Niki Chondrogianni and Efstathios S. Gonos
3. Immunoproteasomes: Structure, Function, and Antigen Presentation
   Deborah A. Ferrington and Dale S. Gregerson
4. Interactions of the Proteasomal System with Chaperones - Protein Triage and Protein Quality Control
   Marc Kästle and Tilman Grune
5. Proteasome Inhibitors
   Boris Cvek
6. Degradation of Damaged Proteins - The Main Function of the 20S Proteasome
   Andrew. M. Pickering and Kelvin. J. A. Davies
7. Changes of the Proteasomal System During the Aging Process
   Martin A. Baraibar and Bertrand Friguet
8. Proteasome and Cancer
   Betul Catalgol
9. The Ubiquitin Proteasome System and Cardiovascular Disease.
   Saul R. Powell, Joerg Herrmann, Amir Lerman, Cam Patterson, Xuejun Wang
10. Role of the Ubiquitin-Proteasome in Protein Quality Control and Signaling: Implication in the Pathogenesis of Eye Diseases
    Fu Shang and Allen Taylor
11. Proteasome and Neurodegenerative Diseases
    Betul Catalgol and Tilman Grune