From Molecules to Networks. An Introduction to Cellular and Molecular Neuroscience

Description:

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease.

Features:

* The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches
* 80% updated and new content
* New Chapter on "Biophysics of Voltage-Gated Ion Channels"
* New Chapter on "Synaptic Plasticity"
* Includes a chapter on the Neurobiology of Disease
* Highly referenced, comprehensive and quantitative
* Full color, professional graphics throughout
* All graphics are available in electronic version for teaching purposes

Table of Contents:

SECTION I. CELLULAR AND MOLECULAR

1. Cellular Components of Nervous Tissue
Patrick R. Hof, Graham Kidd, Javier DeFelipe, Jean de Vellis, Miguel A. Gama Sosa, Gregory A. Elder and Bruce D. Trapp

2. Subcellular Organization of the Nervous System: Organelles and Their Functions
Scott Brady and Peter Brophy

3. Energy Metabolism in the Brain
Gerald Dienel

4. Intracellular Signaling
Howard Schulman

5. Regulation of Neuronal Gene Expression and Protein Synthesis
Cristina Alberini and Eric Klann

6. Modeling and Analysis of Intracellular Signaling Pathways
Paul D. Smolen, Douglas A. Baxter and John H. Byrne

7. Pharmacology and Biochemistry of Synaptic Transmission: Classical Transmitters
Ariel Y. Deutch and Robert H. Roth

8. Nonclassic Signaling in the Brain
Ariel Y. Deutch, Andrea Giuffrida and James L. Roberts

9. Connexin- and Pannexin-Based Channels in the Nervous System: Gap Junctions and More
Juan C. Sáez and Bruce Nicholson

10. Neurotransmitter Receptors
M. Neal Waxham

11. Molecular Properties of Ion Channels
Jason Tien, Yuh Nung Jan and Lily Yeh Jan

SECTION II. PHYSIOLOGY OF ION CHANNELS, EXCITABLE MEMBRANES AND SYNAPTIC TRANSMISSION

12. Membrane Potential and Action Potential
David A. McCormick

13. Biophysics of Voltage-Gated Ion Channels
Diane Lipscombe

14. Dynamical Properties of Excitable Membranes
Douglas A. Baxter and John H. Byrne

15. Release of Neurotransmitters
Robert S. Zucker, Dimitri M. Kullmann and Pascal S. Kaeser

16. Postsynaptic Potentials and Synaptic Integration
John H. Byrne

17. Cable Properties and Information Processing in Dendrites
Michael Beierlein

SECTION III. INTEGRATION

18. Synaptic Plasticity
Ruth Heidelberger, Harel Shouval, Robert S. Zucker and John H. Byrne

19. Information Processing in Neural Networks
James J. Knierim

20. Learning and Memory: Basic Mechanisms
John H. Byrne, Kevin S. LeBar, Joseph LeDoux, Glenn E. Schafe and Richard F. Thompson

21. Molecular Mechanisms of Neurological Disease
Monica Gireud, Natalie Sirisaengtaksin and Andrew J. Bean

Edited by John H. Byrne, University of Texas Medical School, Houston, TX, USA; Ruth Heidelberger, The University of Texas Medical School at Houston, Houston, TX, USA and M. Neal Waxham, The University of Texas Medical School at Houston, Houston, TX, USA